A hotel room in the center of Rome serves as the setting for two young and recently acquainted women to have a physical and romantic one-night-stand adventure that touches their very souls.

Ten years after tracking down serial killer Buffalo Bill (character), Federal Bureau of Investigation Special Agent Clarice Starling is unjustly blamed for a botched drug raid. She is later contacted by Mason Verger, the only surviving victim of the serial killer Hannibal Lecter. A wealthy Child sexual abuse, Verger was paralyzed and brutally disfigured by Lecter during a therapy session. He has been pursuing an elaborate scheme to capture, torture, and kill Lecter ever since. Using his wealth and political influence, Verger has Starling reassigned to Lecter's case, hoping her involvement will draw Lecter out.