When a Hummer in the wrong way runs over an old Fiero, Grissom meets Capt. Brass to investigate the scene. He learns that the Hummer's driver has fled and the Fiero's driver is alive in the hospital. At a car convention, when the host Mr. Daluca opens the curtains to show the latest RV model to the audience, there is a dead woman. Warrick and Det. Louis Vartann learn that the victim is the twenty-nine-year-old model Lisa Schumacher. Dr. Robbins tells Catherine that Lisa was asphyxiated and she had sex before her death. Daluca becomes their prime suspect. Meanwhile, the model Gwen that is working at the convention, goes to the house of her personal trainer Paul Charles to workout and sees him dead through the window. Greg and Sara investigate the crime scene while Dr. Robbins carries out the autopsy. When he sees a black substance in his eye, Hazmat takes Sara and Greg to the decontamination shower. When the body of a boy is found on a bus stop bench covered by a blanket in front of a laundromat, Nick investigates the case. Dr. Robbins tells Nick that the cause of death was asphyxia from heat damage. They identify the victim is Chase Ryan and Nick tries to understand what might have happened to the boy.

Excessive smoke coming from a fire place alerts the fire department, which in turns calls the CSIs as a charred body is found inside the chimney. The body is burnt beyond recognition. A gym membership card found on the body identifies him as the son of the house's owner. The opportunity to search the house leads Catherine and Warrick to look for any evidence about a one-year-old disappearance of a young girl who was on her way to this house before she vanished without a trace.