Sookie must deal with her emotions when her grandmother is the mysterious serial killer's latest victim. She can't block out the thoughts of others and she knows many of the townspeople think the main reason her grandmother is now dead is her association with a vampire. She has a very clear message for them at the woman's funeral. Despite Sam and Bill's pleading, Sookie insists on staying in the house, but she does decide to spend the night with Bill to lose her virginity once and for all. Meanwhile, Jason wrestles with withdrawal symptoms from his 'V Juice' habit, which leads him to lash out at Sookie when he hears about Gram Adele's murder, and he also punches Detective Andy. Also, Tara has a run-in with her drunken mother Lettie Mae at Adele's funeral, who tells her some unsettling facts about herself. Tara then asks Sam to have sex with her at her motel room to look for "something right" between them, while Jason has his night with Randi Sue, and Sookie finally gives in to her carnal desires with Bill.

Eric instructs a werewolf to look after Sookie and accompany her to Jackson, Mississippi; Jason is distracted from his police exams; Bud reaches the end of his rope; Arlene copes with unexpected news; Franklin charms Tara; Eric bequeaths a gift to Lafayette. Haunted by visions from his past, Bill makes a surprising pledge of allegiance.