The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

In the aftermath of a movie theater shooting, the doctors work to treat the victims while Sharon tries to keep the press at bay.

Sharon is visited by the Department of Homeland Security regarding two airplane stowaways who are brought to the hospital with major injuries.

Sharon must decide whether to put her job on the line for a patient in need.

A Saudi prince arrives for a surgical procedure, while Dr. Manning returns from maternity leave and treats a teen with a long history of medical issues.

Dr. Halstead jeopardizes his career when he goes against a family's orders and revives a terminally ill cancer patient.

Doctors Rhodes and Downey set aside their differences to operate on a 9/11 hero with pulmonary fibrosis.

Doctors Rhodes and Choi disagree over a dying patient's request.

Nurse Lockwood is arrested for refusing to take blood from a suspected DUI patient without his consent.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Doctors Rhodes and Downey have a disagreement over a patient's emergency heart surgery.

April and Dr. Halstead treat an alcoholic homeless man with a broken leg.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

Family secrets are revealed when Maggie's sister visits.

An accident at the Chicago Marathon puts the medical personnel into action.

April discovers her TB medication may lead to further problems, while Dr. Choi learns an important lesson as he treats two MMA fighters who are in bad shape.

Dr. Reese endures a long night on the graveyard shift, while Dr, Rhodes is asked to work on a most unusual patient.

Dr. Manning deals with treating a comatose young woman who's pregnant.

The doctors deal with trying family matters.

Robin returns to the hospital with more complications; Rhodes faces competition from a new doctor.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Dr. Manning hits her head while helping the victim of a drive-by shooting; Dr. Rhodes learns surprising information about the woman he dated.

Dr. Choi enlists April's help to figure out how a neighbor got stabbed; Noah misdiagnoses a patient.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to handle the boy's parents; Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information concerning Dr. Reese's father.

The CPD pays Dr. Halstead an unexpected visit; Ethan is skeptical of a woman experiencing chronic pain; Natalie takes care of a cancer patient whose brother refuses to help.

Will must lie to Natalie; Ethan and April uncover compromising information about Emily's boyfriend; Ava isn't sure what to do with a patient who doesn't want treatment.

Dr. Charles and Dr. Choi are at odds over surgery. Dr. Rhodes finds himself in hot water.

Will and Natalie prepare for their big day, but an unsuspecting Will soon finds himself sidetracked.

Halstead hides the theft of his gun from a suspicious Manning. Tensions are still high between Connor and Bekker, who take a risk operating on an HIV-positive patient. Hank breaks down when he sees a patient from his past.

Connor, who is in hot water with the hospital's Oversight Committee, handles a gunshot victim with unexpected ties to Halstead. Maggie feels guilty about the return of a former patient. Charles has an awkward first date.

Natalie and Maggie witness a pickup truck plow through a street fair and must make tough decisions on the fly. At the hospital, doctors and nurses are on high alert with the influx of patients. Dr. Charles' ex-wife comes to town with news.

Dr. Choi and Dr. Charles have difficult decisions to make as a dying man tries to preserve his life with a controversial scientific method. Dr. Marcel and April clash over how to handle a mysterious patient.

Maggie gets unsettling news about a new friend and breaks protocol to support him; one of the doctors from the Med family is rushed into emergency surgery after a violent assault; a social media influencer lets his users vote on medical advice.

A a former patient of Dr. Halstead's resurfaces. Upon Ethan's return, April deals with telling the truth or keeping her secret. Dr. Charles deals with the death of his wife.

Dr. Charles evaluates a 15-year old who is brought into the E.D. after an apparent fall off an overpass. Will sides with Dr. Asher on a risky treatment plan. Tensions run high between Dr. Choi and Dr. Marcel.

Dr. Crockett is visited by two New Orleans detectives who have questions about his past. Dr. Choi puts his life in danger to save a child. Dr. Charles gives fatherly advice to his young daughter.

Dr. Halstead's drug trial continues to be successful. Anna receives life changing news. Noah finds himself in a place even April cannot help.

Ethan teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Archer and Choi go in to the field but the scene brings war flashbacks. Carol's condition worsen and Manning tries to get her enrolled in Halstead's drug trial.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

Vanessa and Archer disagree on how to handle the victim of a motorcycle accident; Scott and Charles deal with a UNICEF negotiator with repressed trauma; Hammer and Halstead treat a high schooler with Addison's disease and a clingy mother.

Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

Marcel helps Blake replace a patient's liver; Taylor tries to prove herself; Halstead continues to pursue the truth about Cooper; Choi gets closer to returning to life in the ED.

Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Will helps a patient with long-haul COVID symptoms. Vanessa reflects on her dating life when she learns that a patient's daughter is having an arranged marriage. A new family is born out of tragedy.

Will and Hannah clash over a patient in need of a kidney transplant. Crockett is faced with a tough decision when Blake is in surgery. Ethan and Archer treat the son of Med's general counsel. Med's family grows.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try and save the survivors. Charles and Med's new fellows, Cuevas, helps a paranoid patient. Scott makes a life-changing decision.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer's son is in danger.

Marcel and Charles treat Lieu's gym buddy; Maggie and Halstead help a robbery-homicide suspect; Asher and Archer use Med's new opiate abuse AI programme.

Goodwin, Maggie and Dr. Marcel help victims of a hit-and-run accident while Dr. Halstead struggles to diagnose a patient with seizures. Dr. Asher and Dr. Archer clash with Jack Dayton.

Dr. Marcel and Dr. Halstead fight against Med's new policies to save their cancer patient.