An young orphan boy is taken in by Grace and Robert E. begins to show symptoms of an unknown health problem.

After a long period of grieving over his lost fiancée, Matthew finally finds love again, but the object of his affection works at Hank's saloon.

When a stranger is convicted of raping a young girl and murdering an old man, he is sentenced to death. Some people are conflicted about whether or not it is right to take "an eye for an eye".

Dr. Mike, nearing her pregnancy's end, has her plans for scaling back interrupted when Cloud Dancing is stabbed and Emma needs an operation. Matthew wants Emma to leave Hank's employment when she's better.

Dr. Mike's mother and two of her sisters arrive with a young Dr. Cook to deliver the baby. Conflict arises between Horace and Myra which ruins Preston's hotel groundbreaking. Sully works to prevent Cloud Dancing's transfer to another reservation.

Dr. Mike leaves in the night to treat Sully, who was wounded by sergeant O'Connor while helping Cloud Dancing. She goes into labor with only Sully to assist her.

Dr. Mike returns to work after giving birth to Katie, but has a hard time trying to balance her professional life, wifely duties, and being a new mother. Sully feels neglected.

Dr. Mike is charged with malpractice and must stop treating patients during the lawsuit, leaving medical matters to the young and reluctant Dr. Cook.

Colleen considers leaving college when the famous singer, Gilda St. Clair, offers her a job traveling the world with her.

Dr. Mike's attempts to befriend a Latin American woman are rebuffed; the Reverend Johnson searches for a teacher to take his place.

When Sully is offered a job helping to survey the new National Park at Yellowstone in Wyoming, Dr. Mike is faced with the prospect of leaving her practice and all their friends and moving into the wilderness. With Sully no longer acting as the local Indian agent and banned from the Indian reservation, Dr. Mike realizes that it is important for him to have work that is meaningful to him. Leaving everything and everyone she knows and taking their new baby into the wilderness, however, is a daunting prospect for her. Meanwhile, as Matthew and Emma think about marriage, Brian agonizes about his first date at the Sweethearts' Dance, and Dorothy teaches Cloud Dancing some ball room dances while he provides her with background on Indian customs for a book she is writing.