Dr. Greene is still haunted by the death of Jodi O'Brien and isn't sure he can function as a doctor. At Susan's urging, he takes the night off but unfortunately for him, the new head of the ER Dr. 'Wild Willy' Swift arrives unannounced. Susan impresses Swift with her handling of many cases on a busy night. She also has to deal with the case of a young man who has had the hiccups for two days but may in fact be suffering from something far more serious. Nurse Hathaway and fiancée Tag are still working out the details of their wedding. Peter Benton's mother is still hospitalized and he will not accept that her age and her injuries mean that she will need permanent nursing care. Dr. Ross is now dating Diane Leeds. John Carter and Deb Chen's attempts at oneupmanship is starting to take on ridiculous proportions.

Dr. Greene is still having trouble dealing with cases in the ER and the new Chief of the ER is growing increasingly concerned. Greene also faces a difficult peer review to examine his handling of the Jodi O'Brien case. Dr. Benton takes on the difficult task of telling his mother that she must be placed in a home with full-time care. Susan's very pregnant sister Chloe returns to live with her. Dr. Ross deals with the case of a young girl with a heart condition while Ross and Carter encounter a patient who refuses treatment for tuberculosis. When Benton asks Deb Chen and Carter to submit their procedures book in a few days, Deb feels she has to get a few more procedures under her belt if she's to best her fellow student. Unfortunately, her eagerness leads to near tragedy for a patient.

Greene finds his marriage falling apart and is concerned at how little time he's spending with his daughter. He also treats an eight week old child with a heart murmur who requires surgery. Susan tries to get her pregnant sister Chloe to take her pregnancy seriously, but her head isn't quite into it. Benton tries desperately to find a surgeon who will operate on a 16 year-old with a severe brain aneurysm that could burst at any time. He's also concerned at his mother's care and is growing ever more attracted to Jeanie Boulet. Doug Ross' commitment to Diane Leeds gets more serious when he agrees to be an assistant coach for her son's little league baseball team.

Doug Ross and Nurse Hathaway treat a girls' basketball team from a local catholic school for meningitis. Their teachers also need to be tested but one of them confides in Hathaway that she may have a particular problem. Green and the Chief of Staff have a disagreement in the middle of a procedure. With the wedding only two weeks away, Tag and Carol Hathaway have to deal with all of the final preparations, not the least of which is writing their own marriage vows. Susan deals with a suicide victim who is using emotional blackmail to keep his girlfriend from leaving him. Susan reaches the breaking point with her sister Chloe and tells her she has to move out.

It's Carter's last day in the ER and finally fed up with Dr. Benton's apparent indifference, rejoices when he learns that he gets to write an appraisal on him. He subsequently regrets his negative input when he gets offered the surgical sub-internship he'd hoped for and learns that Benton gave him a glowing appraisal. He also spends a good part of the day with young leukemia victim who is fed up with life. Benton and Jeanie Boulet's relationship reaches a crossroads. Mark Greene is offered an attending position at the hospital but also learns that he is being sued for malpractice over his handling of the Jodi O'Brien case. The big day for Carol Hathaway and Tag is here but doubts creep in and one of them gets left standing at the altar.

Dr. Anspaugh's 13-year-old son is brought in and Anspaugh asks Mark to look after him. Another old lady who has been raped is brought in.

Dr. Greene's final days are spent in Hawaii with Rachel, teaching her to drive and surf. When he suffers a seizure, Elizabeth is called. Mark refuses to go home. He manages to make amends with his daughter before his eventual death.