Carol Hathaway faces an ethical dilemma when a patient admits that he, and not his friend, was driving the car that ran a red light and killed a pedestrian. She decides to tell Tag about kissing Doug Ross. It's Thanksgiving and the doctors treat an animal rights activist who was attacked by the turkey he was trying to save. Doug Ross is going to the Bahamas with Linda Farrell and he is very much feeling like a kept man. Carter has to treat a transgender woman who has now reached an age where she can no longer pass as a woman. Carter's indifference is the final straw. Susan Lewis continues to worry about Div Cvetic, whose condition seems to be worsening.

Carol Hathaway goes ahead with her plans to adopt Tatiana, but her past history makes her ineligible. Benton continues to trade shifts so he can spend time with his mother but it all catches up with him and he has a run-in with Dr. Hicks. Doug Ross treats an abused child. Green, Benton and Carter take extraordinary measures to save a man they later learned had signed a DNR. A consultant arrives to study procedures in the ER, but all is not quite what it seems. Mark Green's wife Jen has an important announcement. Benton's mother has a serious accident when he falls asleep on the couch.