When Nikki sees barefoot teen-ager Shannon Kelly run over by a car whilst fleeing somebody she sits with her until the ambulance arrives and later visits her in hospital,where it is clear she is frightened of a man. DS Masood tells Nikki Shannon has been sexually abused and suspects Abdul,her estranged stepfather. Shannon turns up at Nikki's and reluctantly agrees to go back to hospital. Meanwhile a gang of young Asian men are picking up and grooming white school-girls for the sex trade. They already have Shannon's friend Amy and go after two more,Hannah and Lauren. The pathologists investigate two seemingly unrelated cases - the remains of a young girl found in discarded airport luggage and a heavily tattooed man,John Dear,who died of toxic poisoning. Then a third corpse is found - that of Amy.

Leo gives evidence at a custody hearing in the wake of a child's death,his opinion over-ruling that of Dr Helen Karamides,which annoys her former pupil Nikki,who sees Helen as the victim of the male establishment and cannot believe the accusation that Helen is retaining tissue samples from past cases. Nikki is also approached by Andy Farmer. His mother Annie was the appropriate adult at the interview with serial killer Arnold Mears,who now directs Annie to the sites of his victims' remains where she collects their bones. Andy wants Nikki to help identify them. Nikki also discovers that Helen had a professional involvement with Mears.

As Leo's replacement Thomas Chamberlain arrives Nikki investigates the murders of Rachel Freedman, shot in the head, and her little autistic son Nathan, who was poisoned. Nikki rejects policewoman Anne Burchett's theory that Rachel killed them both but is perturbed when an impostor, claiming to be Rachel's sister, visits the morgue. At the same time the disfigured corpse of Eva Liron is discovered, killed with the same poison as Nathan. She had been the nanny to French hot shot footballer Isaac Dreyfus and was planning to blackmail him over a sex tape of them both. Jewish Isaac is a controversial figure due to his anti-Muslim sentiments but he denies ant part in the murders. Then another victim, Isaac's agent Mousa, is discovered dead.

Forensic evidence given by Nikki contributes to the release on appeal of disturbed ex-soldier David Bennetto, charged with murdering two gay boys, one of whom he had sex with. DI Rachel Klein is not convinced of David's innocence , especially when a rent boy calling himself Byron Lee is shot dead and David's car is caught on CCTV near the murder scene. The fact that Nikki is dating Bennetto's solicitor Greg Walker makes her partial in the inspector's eyes and she is removed from the case. On the night that yet another gay youngster Charlie Masham is also shot Greg, on a date with Nikki, gets a frantic phone call from Bennetto and they go to his flat where he points a gun at them after he discovers Nikki has found his kitbag containing the murder weapons

The police surround the flat but David hands the gun over to Greg, explaining that it was his father's gun, which he had found and wanted to get rid of. Nikki is verbally abused by Charlie's father and DI Klein wants her suspended but Clarissa and Jack discover that the gun found by David did not kill Charlie and nor could he have killed Byron Lee. The pathologists work out that the real serial killer had an alarming insight into David Bennetto's background and their motive was not sexual but obsessed with having power over others. Circumstances also end Nikki's involvement with Greg Walker.

The team investigate the systematic shooting of a family picnicking beside a river. The case stirs memories of the death of a young woman beside that same river 10 years earlier.