A bus full of students goes missing during the middle of its morning round. It becomes clear that the bus was hijacked. When it is finally located, it is empty save for one student who explains that the hijackers were two of his classmates who want a large ransom.

A priest from a poor area of town goes missing after a car accident in the city. He needs to be found quickly because he is in need of a liver transplant, and a donor liver has just become available but can't wait for long.

A recently engaged woman goes missing during her engagement party. However, the team discovers that her background is full of fraud and scams, which may be the reason for her disappearance.

A talented and famous teenage violin performer, a Russian immigrant, goes missing. The team suspects her family, boyfriend or an apparently creepy fan.

A suburban mother goes missing in broad daylight, similar to another case from years ago where Jack failed to save the victim. Graham Spalding copycats the case only to taunt Jack and seek revenge.

High school student Ethan Sawyer goes missing from his home, where his parents believed him perfect. Hours earlier he returned from team practice with cuts and bruises on his face and the team speculate that he may have had some personal trouble; coach Jim Shirley claimed a drug problem was eradicated, but not quite. It is discovered that, behind the seemingly idyllic life the shy soccer boy is leading, lies a world of teenage parties or even orgies hosted by his 'cool' orphaned best mate Alex Durphy at the home of generally absent uncle and accusations of other illicit activity. The squad must unravel the mysteries in the small town in order to find the boy, including a fake rape allegation from Ethan's first-ever sex partner Jennifer Norton, the lies that turned her unfaithful and a surprising kinship.

An unknown boy is seen being kidnapped and placed into an SUV in a neighborhood with a large population of undocumented immigrants. Despite no missing person report by the boy's family, the team is able to identify him as a local kid who, for one reason or another, had been desperately trying to get his hands on some money by exchanging cans and selling some of his belongings.

A fire-fighter goes missing, just after a large fire in which one of his close friends, despite having been saved from death, ends up badly injured. Although he had told his wife he was heading home, the fire-fighter disappears on the way.

A well-known doctor who had very little life outside of work disappears. It is revealed that she had recently broken up with her boyfriend and had purchased a gun for protection.

A young man goes missing after attending his High School reunion. The team investigates and learns that his happy marriage may be a cover for a struggle with his sexual identity.

A man who invests all of his time as a member of the paparazzi disappears after waiting around to get a shot of a professional basketball player. The team discovers that this man may have been trying to change his life for the better in order to help a radical environmental group.

A young criminal defense lawyer working for legal aid goes missing, last seen in the middle of the night apparently running from people shooting after him. A quick bit of research and it is discovered he has recently been diagnosed with paranoid schizophrenia, yet due to the nature of his work, the FBI isn't certain what he is imagining, and what is really wrong.

A self-help guru is reported missing, but the team learns that he is not who he claims to be, and that he may have staged his own kidnapping as a publicity stunt.

A former-cop-now-bounty-hunter is shot during a raid and disappears. The clues soon lead the team to a corrupt police conspiracy, and Jack takes matters into his own hands to save her.

The FBI investigates the disappearance of Eric Miller, a middle school student who disappeared during a bathroom break. He was only away for about ten minutes, so either he or his suspected kidnappers may have known what would happen. The investigators learn that Eric had low self-esteem and saw himself as part of the loser crowd at school. When his friend tells Agent Johnson about a bullying incident and they also locate a surveillance video from a local arcade showing an older boy pushing him, they realize they may have something other than a kidnapping.

For four years Vivian refused to give up on a dead-end case of a struggling sex addict who went missing. Her perseverance pays off when she receives a break in the case. The hunt for the young woman leads the team on a trail of addiction, abuse, and a strange cult.

A soldier wounded in a firefight in Iraq returns home, only to find his life savings gone, his business closed, and the love of his life with another man. While Jack and Danny travel to Tikrit to investigate what really happened in the firefight, the rest of the team find that the desperate soldier is going to great lengths to get his old life back.

Recently unemployed George Stanley is reported missing by wife Martha, with her hair salon's day earnings. Doted, devoted but job-perspective-lacking son Sean (19) seems to hide having looked for him and his own mild drug past. More crucial proves the old dark family secret, Martha's unreported rape at home, for which a plausible suspect was seen around the very day. Danny is made to reconsider his refusal to testify in favor of his jailed brother at a parole hearing by his new in-laws, and learns their own dark family secret.

A marine biology student is reported missing. The team first suspects the woman's boyfriend, but when new evidence of dead women in different cities points to the boyfriend's identical twin brother, the team struggles to discern which twin is really guilty.

Martin's aunt, a nurse battling cancer, goes to visit a friend but never makes it there. Martin soon learns that his aunt had been assisting terminally ill patients in their suicides. Meanwhile, Jack must deal with his father's medical crisis.

A man who had been fervently trying to prove his son innocent of a convenience store shooting goes missing just before the scheduled execution for this crime.

A football coach who is known for his winning team disappears. The team learns that he recently had an attack of conscience, causing him to crack down on the players' academics and ethics. The team's suspect list is filled with suspended players, angry parents, and university administrators.

An adopted young girl comes to the FBI claiming to have been kidnapped as an infant. The team must start from scratch to find out the truth about who the girl is and what happened to her.

A billionaire's family is taken off their yacht at sea. At first the team suspects enemies of the businessman, but evidence soon shows that the kidnappers may be after the yacht, or what it contains.