25 years after a streak of brutal murders shocked the quiet town of Woodsboro, Calif., a new killer dons the Ghostface mask and begins targeting a group of teenagers to resurrect secrets from the town's deadly past.

After getting a restraining order from Randal Graves (''Clerks'') for Illegal drug trade outside the Quick Stop, Jay and Silent Bob find out from Brodie Bruce (''Mallrats'') that ''Bluntman and Chronic'', the comic book based on their likenesses, has been adapted into a film in production by Miramax Films. In response, the two visit Holden McNeil (''Chasing Amy''), the co-writer of ''Bluntman and Chronic'' and demand royalties from the film. However, Holden tells Jay and Silent Bob that he sold his part of the creative and publishing rights of the comic over to his former friend Banky Edwards. Upon learning of the film, as well as the negative reaction it has received so far on the internet, the two set out on a quest to Hollywood, to prevent the film from being made and tainting their image, or at the very least receive the money from the royalties owed to them.

While Sidney and her friends visit the Hollywood set of 'Stab 3', the third film based on the Woodsboro murders, another Ghostface killer rises to terrorize them.