When the young mother Lori Kyman is reported missing by her husband, Grissom and Sofia meets with Capt. Brass on the highway where her car was found with flat tire. Sara and Capt. Brass go to Lori's house to interview her husband Mark, and they find her best friend Amy Maynard. Lori's stepmother Diane Hoyt arrives and confirms Mark's alibi. Soon Greg finds that the valve of the flat tire in Lori's car was unscrewed leaking the air, and he finds prints. Meanwhile, Catherine, Warrick and Nick investigate the deaths of the hunter Rod Hollis with claws around his neck and a Kodiak bear in the woods. However, the animal is not native from the area. In the autopsy, Dr. Robbins finds that bear was shot twice, by Hollis' rifle and by a Magnum .357 that was used in a robbery and belongs to Aaron Colite. A microchip in the bear shows that he belonged to Clark County Zoo and was bought by a broker.

After a tough day at the work, Catherine invites Warrick and Nick to drink in a bar. She goes alone and meets Adam Novak, a stranger that fives his phone number in a matchbook. He offers to go to her car with her, they kiss each other and Adam turns brutal when she does not want to have sex with him. She hits her head on the door of the car and goes home. While sleeping, Catherine gets a call from Grissom and heads to the crime scene, where Alice Granger is found dead with a shot in her head. When Det. Vartann find her car nearby the bar where Catherine was, she goes with him to investigate. When she finds a matchbook in the belongings of Alice with a phone number, she heads home to find Adam's matchbook, but it has been thrown in the garbage. Their further investigation indicates that her ex-boyfriend, Jeff Simon, might be the killer, but he had a strong alibi. Catherine tries to tell to Grissom about her possible involvement in the case, but he does not give much attention to her. But when a second victim is found with the same M.O., they realize that the killer might be the same.

Catherine investigates the murder of a young mother who claimed God got her pregnant, while Grissom witnesses a very shady trial.

In a courtroom, Det. Sofia, Dr. Robbins and Nick go to the stand to testify about the murder of the popular high-school student Stacy Vollmer, who was found wrapped in a shower curtain and buried in a flower bed in her school. The prime suspect is Marlon West, and all the evidences point to him. When his twelve-year-old sister Hanna goes to the stand and confesses the crime, the judge gives seventy-two hours to the prosecution to check the evidences to proceed the trial without reasonable doubt. Who killed Stacy Vollmer?