A thief is found dead from blunt force trauma to his head in a pottery store where he was evidently trying to crack a safe. The team dusts the store and finds the fingerprint of a girl who has been missing for the last 20 years. Sara and Warrick find what's left of an old woman in her rocking chair. The two believe that they are witnessing a case of spontaneous human combustion. To prove it, Sara decides to conduct an experiment by herself.

Grissom, Sara and Warrick investigate the apparent hit and run of a young man...they soon discover he was deaf. Meanwhile, Nick and Catherine are attempting to solve a mass murder in a coffee shop.

A casino was brutally but clumsily robbed by at least four trigger-happy fiends, the men of which wore female wigs. Painstaking identification efforts lead to ex-con serial killer Tammy Felton and accomplices, but one by one is found murdered themselves. The solution comes only after links are found with the bizarre shooting of a desert hamlet's only store's clerk, discovered by state trooper William Spencer, who messed up the crime scene despite long experience.

While performing on the stage, the comedian Dougie Max dies. Grissom, Catherine and Capt. Brass investigate the case and Grissom and his team conclude that he was poisoned by the expensive bottled water Innoko. When a teenager dies in a convenience store, Warrick is assigned by Grissom to investigate the case, and soon he finds that the youngster had drunk Innoko water. Grissom finds that the bottles came from the same lot, and was not a tampering case. Meanwhile, Brass asks Nick to reopen the case of Shelley Stark, who died in an accident in a bathtub and Brass did not call any CSI investigator. He has just seen her husband with a hot woman driving a Ferrari and he is intrigued, since the man was inconsolable. Nick and Sara reopen the case and find new evidences.

Sheriff Rory Atwater is leaving the Orpheus hotel and witness a car bombing, where the driver, the valet and the bellhop die. Grissom and Catherine arrive to investigate the crime scene and gunshots start. Grissom finds that the bullets are in the trunk in bag. Nick and Capt. Brass help the investigation. Soon they learn that the driver is Air Marshall Adam Watson, and the car was rented in an agency. Nick puts together the pieces of the bomb, which was a pipe bomb connected to the car clock. Soon they conclude that the victim might have been the previous user of the rented car since the timer was not accurate. Meanwhile, Sara, Warrick and Det. Louis Vartann investigate the death of Amelia Reuben, who is the wife of the successful singer Myles Reuben. They conclude that Myles, his manager Sam Hopkins and a hotel waiter were the last persons to see Amelia alive, and the autopsy and Greg's investigation concluded that she was poisoned.