A body falls out of the sky, literally. The cause of death is suffocation but the body bears no signs of strangulation.

When a body is found in a foam party, he is identified by Grissom and Capt. Brass as the male prostitute Trey Buckman. Meanwhile, Catherine and Nick investigate a decomposed body of the also male prostitute Croix Richards in his apartment. Catherine receives a phone call from Eddie's phone, who is with Lindsey, with poor reception, but soon she learns that Lindsey is screaming and she leaves the crime scene to seek out her daughter. She finds Lindsey in a car in the water but she rescues her. Sara and Det. Vega investigate the case and they suspect that Eddie is dead. Meanwhile Grissom concludes that both victims may have been dead by insulin and they were employees of Lady Heather. Grissom and Catherine visit the suspect Rebecca and meet her husband Steven McCormick that tells to them a weird story. Then he goes with Capt. Brass to Lady Heather's house. Grissom has a personal moment with Lady Heather and when he learns that she is diabetic, he requests a warranty to get her insulin.

While performing on the stage, the comedian Dougie Max dies. Grissom, Catherine and Capt. Brass investigate the case and Grissom and his team conclude that he was poisoned by the expensive bottled water Innoko. When a teenager dies in a convenience store, Warrick is assigned by Grissom to investigate the case, and soon he finds that the youngster had drunk Innoko water. Grissom finds that the bottles came from the same lot, and was not a tampering case. Meanwhile, Brass asks Nick to reopen the case of Shelley Stark, who died in an accident in a bathtub and Brass did not call any CSI investigator. He has just seen her husband with a hot woman driving a Ferrari and he is intrigued, since the man was inconsolable. Nick and Sara reopen the case and find new evidences.