A mysterious illness leaves little hope when a group of homeless kids enter the ER and one of them believes that Neela is a guardian angel in blue; Abby and Kovac clash over a possible case of domestic abuse; Pratt makes a shocking discovery about his brother, and Weaver is unexpectedly called into action when her television appearance becomes a real emergency.

It's Christmas in the ER. A homeless boy sends Gates and Ray on a mission. Meanwhile, in the ER, Neela oversees an unusual kidney transplant case; Sam takes a stand when a patient is dumped in an alley by another hospital; and Morris plays Santa for a special girl and learns the meaning of Christmas.

Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.