Confident second-year resident Pratt wants to prove his abilities when he works the graveyard shift (11 p.m. to 7 a.m.), but his heroics sometimes backfire. Pratt shows contempt for a man, Ed Gamble, who presents no symptoms of disease but temporarily loses his speech. Chen continues to get in the way of Neela's progress as her jealousy regarding Chief Playa Pratt's flirtations with everyone who wears a skirt reaches new levels of ridiculousness.

Pratt and Kovac clash over a miscarriage-prone young woman who arrives to deliver a premature baby. Pratt wants to make heroic efforts to save the unborn child, while Kovac is adamantly against spending vast amounts of money to keep the forever sickly baby alive.

To everyone's amazement, Lewis makes a date to share a home-cooked dinner with the elderly Ben Hollander, her depressed patient who is going blind.

On Thanksgiving Day, a helicopter crash outside the ER leaves several injured. Alex tries to bring Sam and Luka together.

Neela helps treat two Amish teens who were in a car crash. Sam argues with Dr. Kovac when he pays too much attention to her son.

Carter returns from Africa full of surprises including a new love, Makemba ("Kem"). Pratt accidentally breaks a patient's neck while doing an unsupervised intubation. A whole nursing shift cannot go home until they find one missing Valium.

Abby and Neela are assigned to a month-long rotation in the neonatal intensive care unit where they experience emotional roller coasters while caring for the sick infants.

Dr. Carter's girlfriend makes an impression as she observes ER operations. Dr. Gallant is almost shot during a domestic incident. Dr. Weaver dedicates a center to the memory of Dr. Romano.

Dr Morris agitates a patient who then leaves, steals a tank, and rampages through Chicago on his way to County General. He makes it all the way to the ambulance bay before the CPD finally stops him. Sam tries to figure out her relationship with Kovac while Gillian shows up at the ER to cement plans for dinner with Carter, Kem and Kovac - making things that much more difficult. Neela confronts Frank about his arrogant bigotry, bluntly telling him she wants nothing from him but silence from this point forward. During the initial onrush of patients due to the tank rampage, Frank has a heart attack which is, thankfully, caught. Frank's wife and daughter show up and are rushed up to the cath lab where Dr. Pratt is helping Dr. Kayson keep Frank alive. In the end, Neela winds up in the family room with Frank's family listening to them describe a side of Frank that no one has ever seen. Meanwhile Kovac treats a 13 year old with chlamydia and counsels him to contact his sexual partner - which turns out to be quite a few teenage girls.

Pratt struggles to diagnose a woman who suffers mysterious chronic seizures. An attractive woman, Campbell, informally accuses flirtatious Pratt of sexual harassment. Abby ponders how to get her contentious patients' attention during her psychiatric department rotation.

Carter takes Kem to the hospital to check on their baby since it's not kicking anymore.