Can House save a high powered female executive from the same problem that has left him in constant pain? A new head of the hospital board could cause problems. Clinic cases: A boy and his mute dad.

While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.

House and the team struggle to diagnose one patient in order to save another. Clinic Case: College student claims he has the hots for heifers.

A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.

A young man is stricken during sex with his girlfriend, and House must determine why his organs are suddenly shutting down. Finding the cause is like looking for a needle in a haystack.

This is a hectic day in Cuddy's life from 5AM to 9PM. Giving an insurance company an ultimatum could bankrupt the hospital. She fires an employee for theft. Her child's sick. A patient won't pay for a reattached thumb.

Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House's team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a bold decision regarding the patient's treatment.

A surprising visitor makes House an offer he can't refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being administered by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park. After several inconclusive treatments and with time running out, House and Dr. Park are left with one last option to examine the patient's medical history that could compromise House's conditional agreement with the hospital. Meanwhile, House makes an effort to reconnect with Wilson despite a cold reception.

When Benjamin suddenly collapses after making a rare and generous donation, House and Dr. Chi Park are convinced that his extreme altruistic behavior may indicate a deeper medical disorder. With no definitive explanation for Benjamin's loss of consciousness and unresponsiveness to treatment, House pushes just the right buttons to recruit former prison doctor Jessica Adams to volunteer her time and expertise to the case. Benjamin then makes a bold but life-threatening offer that could save another life, and the team must diagnose his disorder before he puts his own life on the line. Meanwhile, Adams and Park test each other's outlook on generosity and gratitude, and Thirteen's guilt conflicts with her pursuit of personal happiness.