After Alisha was tragically murdered in last season's final episode, and Simon traveled back in time to when he sacrificed his life to save hers, Curtis and Rudy continue their community service. Seth returns to pick up Kelly's belongings, as they have decided to move to Africa after a visit where Kelly realized she could use her power to deconstruct land mines. Two new offenders join the community service team: Jess, who has X-ray vision, and Finn, who is a telekinetic. The new offenders quickly realize something is not right. Rudy, Curtis, and Seth (and eventually Jess and Finn), have been infected with some sort of virus after a badly hurt man, with a briefcase handcuffed to him, stumbles into the community center and collapses at their feet. The group becomes so obsessed with obtaining the briefcase, that they're ready to murder each other over it. Finally, as the group tries to get the briefcase from Finn on the roof, the hurt man lunges for it and falls to his death, ending the virus. The new probation officer finally arrives, and is creepy and, possibly psychotic. Finn goes home, and we see that he has a girl bound and gagged in his flat.

When the misfits model for a sculpture class for the blind, Curtis and Rudy both fall for student, Ally, but both are rejected as her guide dog picked up the power of telepathy in the storm, and is conveying their weaknesses to her. Rudy discovers Sadie tied up in Finn's flat and lets her go. Finn explains that following the storm, Sadie picked up the power to control him using violence, but he loves her and does not want to leave her, hence his actions. Sadie counters by saying that she was only curing his slobbishness. Seth agrees to take Sadie's power from her, but in doing so, splits the couple off as they fed off each other's bad points. Both homeless Finn and Rudy move into the Community Centre, where Curtis falls for alluring probation trainee Lola, and Jess is attracted to handsome barman, Alex.

Finn is confused when stepmother Lisa tries to seduce him and even more so when Mike,the man he believed was his father,says Finn is not his son after all. Curtis makes headway with Lola but Jess is annoyed when Alex ducks out of a date. A third Rudy,a violent criminal just out of jail,turns up,frightening the gang with his violent talk and taking over the other two Rudys. After he has got Jess to admit to an attempted suicide after a boy dumped her he attacks Greg but is himself killed by Jess in order to release the other Rudys.

Finn and Rudy have problems over sharing their illicit room in the centre but,after Rudy has been banished to a room full of slugs,decide they miss each other. Lola tells Curtis that ex-boyfriend Jake was violent to her and gives Curtis a gun to threaten him. During a fight the gun goes off,killing Jake but when Curtis discovers that Lola is an impostor he briefly resurrects him and learns that,due to the storm,Lola became a man-hater turning men against each other. However Jake must be killed again to prevent him becoming a zombie. Curtis locates Lola,who now has another boyfriend,whom she plans to use to destroy Curtis,aiming to kill them both and say they shot each other but after she has shot him Curtis briefly comes back to life as a zombie and kills her before shooting himself.

Using old photographs Finn tracks down his real father,Dan,who has terminal cancer but is being kept alive by his daughter Grace,using the power she got in the storm. Dan tells Finn that he is in pain and wants Grace to let him die but she is unhappy when Finn confronts her with her father's request,saying she does not want to be alone. Finn assures her that he will always be there for her. Finn also shadows Alex,believing him to be gay as he keeps meeting other boys. Jess refuses to believe it and has a date with Alex,who kisses her but stops short of sex. However Alex tracks down a particular young man and makes a very bizarre demand of him.

Rudy takes Jess,Finn and Alex to a party held by his drug-loving friend Richard,where they discover they have the number of their sexual partners indelibly written on their foreheads. Richard is cowering in a cupboard,terrified of 'the White Rabbit',an apparent mutant. Bored with the party Finn and Rudy gate-crash a funeral where Rudy talks to the enigmatic Nadine,who rushes away mysteriously at midnight. Following her he is pursued by the giant white rabbit,which has just killed a girl but he escapes and gathers the boys together in time to rescue Jess from the rabbit,helped by a party-goer called Abbey. Next day Alex shows Jess why they cannot have sex. His penis was stolen by a transgender man.

Abbey sticks around at the Community Centre,claiming to be on community service when Greg questions her presence. She meets Tara from an ante-natal class who does not want her baby and transfers it to Abbey. However Abbey initially wants to keep the child,admitting that she lost her memory in the storm and wants something to make her feel she belongs. When Tara returns though Abbey feels sorry for her and reverses the process. Alex locates James, the transgender man who took his penis and tracks him down to a karaoke club, where the other misfits are amazed to see the threatening Greg sing a sensitive song. James gives Alex back what is his. Nadine turns up to see Rudy but rushes away again and when he follows her he discovers that she is a nun.

Rudy is perturbed that the nuns try to prevent him from seeing Nadine and,along with Abbey and Finn - who have just had sex - rescue her from the convent. However Alex's new-found masculinity has made him sexually selfish and Finn argues with him since he has cheated on Jess. Being confronted by anger which stresses her out unfortunately unleashes Nadine's special power - the ability to summon the Four Horsemen of the Apocalypse,which she does despite herself. The misfits are attacked by the horsemen and,although Finn uses his special power to save Abbey,Nadine sacrifices herself to make them disappear for good,leaving Rudy heart-broken. Alex is also stabbed and rushed to hospital.