Simone and Sipowicz look into the death of a young woman whose body is found burned beyond recognition, except for a tattoo on her back. Detective Vince Gotelli arrives from another precinct to assist Simone and Sipowicz with their case and puts his two cents in, much to Sipowicz's delight and one of the victim's roommates becomes the prime suspect. Meanwhile, Medavoy pulls double shifts for himself (to get away from problems at home) and is assigned to watch an informant who has a penchant for playing poker with his friends.

Sipowicz returns to work after his successful prostate surgery, but apparently too soon, for he has an accident while interrogating a suspect. He is given desk duty to help Simone and Russell investigate the murder of a woman's boyfriend by her ex-husband, the ex-husband later revealed to be searching for his daughter who's gone missing while in the ex-wife's care. Meanwhile, Simone is called upon by Detective Nick Savino to help investigate a missing persons report that is being filed by the nephew of one of Simone's apartment tenants. Based upon past exchanges between the missing woman and Henry Coffield, another building tenant, Coffield becomes a suspect. Former administrative aide Naomi Reynolds shows up at the station, now wearing a private security uniform and speaking in her natural Australian accent, to visit Simone, hoping to tell him that her situation with the INS was resolved and she is now furthering her pursuit to one day become a NYC police officer.

Youthful detective Danny Sorenson joins the squad and, during a multiple homicide investigation, discovers that his new colleagues have yet to recover from Simone's death.

The detectives investigate a multiple homicide at a fast food restaurant; an addict gives his 5 & a half year-old daughter to a drug dealer as collateral on an overdue loan; Internal Affairs reopens the Kirkendall case.

Sipowicz and Sorenson investigate the murder of an exotic dancer; Sipowicz and Medavoy act as elderly decoys to catch some street thieves attacking old people outside a local bank.

Sipowicz and Sorenson investigate the murder of a drug dealer, while Sorenson continues to see the stripper, Kristen, who draws him into a favor for the owners of the Tailfeathers club.

Sorenson is missing, and a stripper is found murdered in his apartment. Medavoy and Jones investigate a killing, but the suspect identified by an eyewitness has a seemingly unshakable alibi.

The squad investigates two homicides: a gay man who hit his head after being punched out and another man shot on the street. Rodriguez is set-up by iab to take a bribe from an old friend.

The detectives investigate the shooting death of a man whose brother is a registered sex offender; and when Captain Fraker's trial gets underway, Sipowicz worries that his own testimony may have harmed the prosecution's case.

While investigating a random stabbing, Sipowicz becomes obsessed with his own mortality after he's nearly gunned down by a murder suspect; Medavoy takes a job as a bouncer.