Lex returns to Smalville and the Lex mansion, and invites Dr. Helen Bryce for a second honeymoon while trying to find out if it was her or his father who attempted to kill him. Meanwhile, Clark also returns to Smallville and the Kent farm, but Morgan Edge finds him and threatens to kill Jonathan and Martha in to get what Clark stole from Lionel Luthor's safe, which is the stolen vial of Clark Kent's blood. With the financial status of the Kent family in dire straights, the farm is sold in an auction, but there is a surprise in the end. Also, Lana tries to declare her love for Clark, but he rejects her love out of fear that she may discover his secret. Clark also returns to Smallville High and to the Torch newspaper under Chloe who continues to investigate Clark's origins.

While returning home after leaving Jonathan Kent in the hospital recovering from a heart attack, the truck of Martha and Clark is almost hit by two cars racing in the road. For the greatest surprise and deception of Clark, one of the drivers is Pete Ross, who has become the friend of the bad element Jason Dante whom is using meteor-rock synthetic fuel to win at drag races. Pete does not accept Clark's advice and gets into serious trouble when Dante wants $20,000 of losses after thinking Pete betrayed him to the police. Meanwhile, Lex investigates the prominent Dr. Lia Teng about her research of blood platelet with Adam Knight, and Lana feels threatened by the mysterious dark secret of Adam after finding out that he "died" of a rare liver disease and learns about the mysterious blood platelet drug he is taking to keep himself alive.

While in an elevator at Luthor Corp with another girl during a class field trip, Clark is forced to use a few of his abilities when the cable of the elevator accidentally breaks and in the process, the student, Alicia Baker, witnesses Clark's ability of heat vision and punching through steel and in return, Alicia 'teleports' herself and Clark out of the elevator. Clark confides his secret to Alicia who confides her secret of being a meteor-rock mutant with the ability of teleportation. Soon, Clark and Alicia start to get closer and he starts to really think that Alicia could be the one for him. But Alicia on the other hand, turns out to be an obsessed sociopath who wants Clark... NO MATTER WHAT! When Clark starts to realize Alicia's obsession with him, he decides to put an end to their brief relationship. But Alicia won't settle for second and sets off to kill Clark's true love Lana. Elsewhere, Lana finds a journal that Adam has and finds out that he has been spying on her and Clark... under orders from Lionel. So, Lana turns to Lex for help with this situation.

When Jonathan goes to Smallville Medical Centre for a physical examination, his doctor diagnoses arterial blockage and recommends a triple bypass heart surgery procedure. Meanwhile, Vince Davis, the older brother of Clark Kent's friend Garrett Davis, needs a liver transplant - but does not receive one and he dies. His body is sent to Metropolis to be the next test subject of Lionel's experiment by Dr. Lia Teng, who injects his dead body with experimental blood platelets and revives him. When Vince gets sick again (because he needs the life-sustaining blood injections on a daily basis), the unstable Garrett loses control and becomes a threat to the patients, employees, and visitors of the hospital by showing up at the hospital with a kryptonite-infused bomb strapped to himself, threatening to blow himself up unless his brother receives a new liver transplant. Clark must try to find a way to defuse the situation during Jonathan's heart surgery, while the overzealous Sheriff Adams wants to kill Garrett in any way possible... even at the expense of the hostages. Meanwhile, Chloe does some investigating for Lex of Dr. Teng and learns about the mysterious blood platelet serum she's manufacturing and about the first test subject: Adam.

While working as a volunteer with Pete at Smallville Youth Center, Clark receives a distress phone call from Lana, who is shot by Adam. His further investigation shows that the call was made from the future because of a time/space porthole created by a massive electrical surge from a downed power line fitted with meteor rocks, during a coming thunderstorm. Clark must try to save Lana and change the future. Meanwhile, Lionel Luthor shuts down the obscure Merton Laboratory and the research that Dr. Lia Teng is developing with blood platelet, which were finally revealed to have been developed from the vial of Clark Kent's blood. Adam becomes aware that he has less than 12 hours to be injected with the serum, otherwise he will die. He escapes, kills Dr. Teng and her whole team, and Lex is framed as responsible for the mass murder. Adam then sets out to find Lana to know if she still has an extra vial of serum for him. Lex later meets with an FBI agent, named Frank Loder, who enlists his help to bring down Lionel Luther, who also confides in an associate of his about his research and reveals the reason for it: Lionel himself is dying from a rare liver disease.