Lex hires Dr. Curtis Knox who claims that he can "cure" someone from being a "meteor freak," changing their lives. Chloe takes an interest in this, but Dr. Knox may have another secret as Clark finds out that Dr. Knox is an ageless immortal who needs blood from kryptonite-infected people to keep his young wife eternally young. Meanwhile, Kara makes an alliance with Jimmy to find out where her spaceship crystal is being held, while John Jones warns Clark that Kara is dangerous and tells him to find the Kryptonian crystal before Kara does. Elsewhere, Lana secretly watches Lex through her Isis Foundation to help meteor freaks.

Clark hears the voice of his biological mother, Lara, calling for help from Kara's crystal and decides to release her, despite Jor-El's warnings. Lara and Clark reunite and she gives him Jor-El's ring, which contains blue kryptonite. As Clark puts it on, he realizes Zor-El manipulated the whole thing and that blue kryptonite strips him of his powers, enabling Zor-El to take control of the Fortress of Solitude. Meanwhile, Chloe and Lex each discover Lois and Grant have been seeing each other and warn them to stop.

Clark's first day on the job at the Daily Planet begins with a bus exploding right outside the building, which leads him and Lois on a trail of someone who might be infected by kryptonite. Chloe finds a runaway teenage girl, named Bette, whom Chloe suspects is involved in the explosion when Bette (whom will later become the fire-starter Plastique) has the meteor-rock power of pyrokinesis. In the meantime, Chloe also meets a local medic, named Davis Bloom, who takes an interest in her, even though she's engaged to Jimmy Olsen. Elsewhere, Tess meets Clark for the first time as she takes over the Daily Planet in Lex's absence and immediately senses something not right about him.

Oliver gets a step closer to finding Lex, but Clark refuses to help for the time being, due to Chloe's special day, while Lois finds she has special feelings for Clark, who has a surprise (or two) waiting for him at the wedding reception.