On the last day of Smallville High before graduation, the emotionally disturbed and frustrated photographer of the Torch, Brendan Nash, feels rejected by the Universities and decides to abduct some schoolmates to stay with him forever in a replica of the school. He uses his power of 'Medusa Touch' of turning people into stone by mere touch, and brings Lana, Chloe, and other successful schoolmates to the place. While Clark teams up with the nosy Lois to find the other students, he also talks with Jonathan and Martha over his college choices after graduation. Meanwhile, Genevieve and Jason Teague kidnap Lionel and Lex Luthor and hold them hostage in a remote mountain cabin and torture both of them to try to retrieve the second mystical stone that Lionel took from them.

Lana tells Clark that she is moving to the Metropolis University and she is accepted in the Tri Psi Sorority, a sisterhood with hot vampires led by Buffy Sanders, and Lana is transformed in a vampire. Meanwhile, the chief-editor of The Daily Planet, Pauline Kahn, denies an intern position to Chloe, but in the end she proposes Chloe to write a good story to prove that she might be part of the team of reporters. Meanwhile, Lex intimidates Professor Milton Fine, but in retribution he shows a dossier about the secret experiments that Luthorcorp is performing in the campus of the Kansas University. When Clark sees Lana at Chloe's room, he believes she is with a hangover; later, he goes with Lana to a Halloween costume party promoted by the Tri Psi. When Lana attacks Chloe, Clark discloses the truth about Buffy and her sisterhood of vampires and tries to find a means to save Lana and Chloe when she gets bitten by the evil vamp Lana.