A drug dealer's appeal of the federal death penalty is rejected by the Supreme Court, which upholds the death sentence with execution scheduled for the following Monday. One of the defense lawyers on the case is Sam's old high school bully, and he appeals directly to Sam to involve the president. During a weekend in which he was supposed to be in a yacht race, Sam opts to stay at the W.H. and try to convince his fellow staffers and ultimately Bartlet that the president should commute the sentence. Meanwhile Josh, after a night of heavy drinking at a bachelor party, meets congressional campaign manager Joey Lucas while is hung over. She assails him for having the DNC cut off funding for her candidate, but the decision was deliberate, as the W.H. likes the conservative nutjob currently holding the Calif. seat. Opinions on the death penalty are exchanged throughout the weekend, including those of Quaker Joey Lucas and Toby's rabbi, and Bartlet winds up calling both the Pope and his old parish priest from N.H. for counsel.

The President meets Zoey's new bodyguard on a 20-hour trip to California; Josh tries to keep a fund raiser from being canceled; Leo needs the VP to break a 50-50 tie in the Senate.

A newly energized administration prepares to take on soft money, increase addiction treatment, and remove mandatory minimum sentencing.

The staff waits for a poll to tell them if their new, activist policies are moving them in the right direction. C.J. feels like her opinions are being discounted.

While a live TV show is broadcast from the West Wing following the State of the Union, the staff must covertly deal with a hostage situation in Colombia. CJ learns that a special guest at the state of the union has a black mark on his record that could taint the administration. Ainsley Hayes is afraid to meet the President in person.

President Bartlet is fighting a war on two fronts as he tries to rescue hostages in Colombia and deal with explaining to his wife why he's breaking his word to her by running for a 2nd term.

White House Counsel Oliver Babbish interviews CJ once she learns of the President's condition. The First Lady learns she may be legally vulnerable. Donna frets over news of a falling satellite.

With hypothetical polling numbers showing them it will be political suicide, staffers prepare to announce the President's condition. As they do, a military crisis flares up in Haiti and Josh faces off against two senators who are against the Government's tobacco industry suit. But as badly as the day seems to be going, a tragedy will come from a car wreck at 18th and Potomac that will affect everything.

The staff is hunkered down in the Bartlets' hometown of Manchester, N.H., where they work with political consultants Bruno, Doug and Connie on the president's official announcement that he'll be seeking a second term; meanwhile, they all lament various W.H. events of the previous four weeks, including a huge strategic mistake by Josh, a pivotal FDA announcement scheduled for the same day as the president's speech, an ongoing battle between then president and first lady, and a major press room gaffe by C.J.

With the staff all bickering with one another in Manchester, especially adversarial speech writers Toby and Doug, who angrily disagree about whether Bartlet should make a public apology for lying about his MS, and with the president sniping at everyone, the second-term announcement speech is locked. Abby ultimately forgives the president for deciding to run again without discussing it with her, and he ultimately apologizes to the staff in private for keeping his condition from them, which they expect will soon lead to a whole slew of grand jury subpoenas.

On the night of the State of the Union, Sam has to explain the process of writing the speech and grading reaction to it to a magazine reporter (Traylor Howard) throughout the evening; C.J. arranged the coverage aware that the reporter, Lisa Sherbourn, is Sam's ex-fiancée; flashing back to the speechwriting process, we see the president dining with several of Abbey's medical colleagues, and they ponder the future of cancer research, motivating Bartlet to ask that a section be added to the SOTU in which he calls for U.S. scientists to find a cancer cure by 2012; the staff, convinced that the Congressional censure is weighing heavily on the president, tries to talk him out of this bold but risky proposal.

Sequestered in North Carolina to prepare for the one and only debate between Bartlet and opponent Robert Richie, the staff and several consultants (incl. Andrea Wyatt and Joey Lucas) flash back to the days just before and after the president's first inauguration, which were marked by an ill-advised choice for attorney general and ongoing concerns about fertility for then-married Toby and Andrea. In the present, Sam plays Richie in mock debates and raises Bartlet's ire, while Leo and the joint chiefs try to convince the president not to treat increasingly aggressive Qu'mar, whose defense minister Bartlet ordered assassinated (late last season), with kid gloves, and the staff keeps pestering Toby about his on-again, off-again relationship with Andrea, until he makes a startling revelation.

In inexplicably finishing the speech early Toby is left with nothing to do. However, the State of the Union speech needs testing, so Toby flies out to meet Joey Lucas to perform mall tests.

Josh and Santos visit New Hampshire to launch the presidential campaign. Josh has experience running national campaigns and has a clear idea about what candidates should and shouldn't do to get elected, but Santos's approach differs dramatically: he believes in talking about big ideas rather than saying whatever he needs to do in order to win votes. This difference in opinion combined with conventional wisdom that says Santos has no chance of winning threaten to sink the campaign before it's begun. Will and Donna are also in New Hampshire, running Vice President Bob Russell's campaign - which puts their interests at odds with those of the Santos campaign.

Four days after the Democratic convention, Josh begins to staff up the Santos campaign. With Santos and Leo effectively strangers - and Leo not an experienced campaigner - adjustments of roles and responsibilities are required in order to deliver a strong and consistent message. The White House prepares to launch the military Space Shuttle on its rescue mission to the Space Station amidst growing suspicion that proof of its existence was deliberately leaked by someone in the Administration. The Republicans offer Bartlet a concession on an education bill in an attempt to drive a wedge between him and the Santos campaign.

Despite vigorous campaigning, the Santos campaign still struggles to articulate its message and keep the focus on domestic issues rather than gossip and trivia. Although Santos served decades in the military and remains in the reserves, Vinick still appears the stronger candidate on national security issues due to stereotypes about Republicans and Democrats. The White House's decision to halt their own investigation into the leak is a savvy legal move, however it could prove to be costly politically: while Vinick can slam the President for this decision, it's not so easy for Santos to do so. Josh reluctantly recruits help with running the campaign when it becomes obvious that he's trying to do too much himself.

President Bartlet and his current and former staffers come together for Leo's funeral.