Josh trumps a potential Democratic challenger in a masterful political move and then hires the challenger's chief of staff and ex-girlfriend Mandy Hampton. Toby tries to warn Sam away from his friendship with the call girl, but to Toby's horror, Sam seems intent on reforming her. CJ tries to spin the latest clash between President Bartlet and Vice President Hoynes. After an American plane is shot down carrying Bartlet's physician, Bartlet's response leaves Leo worried about the President's response.

After a speech touting the success of a gun control bill, the team learns they are actually five votes short. The fight to get them back puts a strain on Leo's marriage and Josh's relationship with numerous Senators. Toby finds out he may have accidentally participated in insider trading.

A crucial banking bill is at risk when political rivals of environmentally sensitive President Bartlet attach a land-use rider to it that would allow strip-mining some of the Montana wilderness. C.J. tries to stamp out rumors that the Chief Executive chastised the Vice President during a cabinet meeting. An overworked Leo isn't too keen on his independent daughter Mallory dating the handsome Sam. C.J. continues to fend-off the romantic charms of a perceptive reporter with a knack for sniffing out juicy stories. Former lovers Mandy and Josh clash over the administration's attempt to jettison the land-use rider that might also ruin passage of the more important banking bill.

The President meets Zoey's new bodyguard on a 20-hour trip to California; Josh tries to keep a fund raiser from being canceled; Leo needs the VP to break a 50-50 tie in the Senate.

A stealth fighter is shot down over Iraq, leading to Bartlet ordering a military rescue as Toby worries about his brother trapped on a space shuttle orbiting the Earth. CJ deals with the ramifications of misleading the press about the rescue as the staff prepares for a town hall meeting that night. The town hall meeting goes well until the President leaves...and shots ring out.

The President is rushed to hospital following a shooting; staffers field questions on protection measures and executive authority. Flashbacks show how key staff members joined the Bartlet campaign.

Josh finalizes a $6B health care plan that has strong support from both parties in both houses and appears to be a slam dunk for passage, but 78-year-old Senator Howard Stackhouse pulls a last-minute surprise--he wants money added for autism research or he'll filibuster. Thinking it's just a bluff, Josh blows off the senator, who then filibusters for more than eight hours while the WW staff waits desperately to begin their weekend with the episode unfolding as staffers write e-mails to their family members describing the evening's action. Elsewhere, Sam tries to eliminate various costly government documents, for which he's taken to task by a very young intern.

After a fatal shooting in Texas, the president asks Hoynes to go down there and speak out for gun control, in spite of his history opposing it. Donna makes a gaffe in front of the Congressional committee. Leo argues with an old friend about the creation of an international war crimes tribunal.

In an episode dotted with flashbacks, Leo and his attorney Jordon Kendall (Joanna Gleason) face a Congressional inquiry into whether the president lied to the American people regarding his MS, but this particular day of hearings concerns itself more with Abby and her secretly medicating Jed, and later with Leo's having fallen off the wagon during the campaign (a politically motivated Republican rep on the committee witnessed Leo drunk in his room three days before the nomination); we see the meeting in which Leo talked N.H. Governor Bartlet into running for president, introducing his idea, "Bartlet for America", on a cocktail napkin, which the president later frames and returns to Leo as a gift in thanks for all he's done for the president over the years; Cliff Calley, Donna's boyfriend and special counsel to the judicial oversight committee, asks the committee chair to halt the inquiry before the rep can compel Leo to admit his personal transgression; Leo asks Jordon to Xmas Eve dinner.

On a typical night in the west wing, Sam returns from a hockey game and Josh asks him to meet with V.P. Hoynes about saving an education bill. Back at the W.H., Josh, Toby, Leo, C.J., Larry and Ed all meet about the prospect of replacing Hoynes on the ticket in the next campaign. Bartlet helps Charlie do his federal taxes, and while both think Charlie should expect a refund, thanks to last year's so-called economic stimulus, he instead owes money to the IRS. A security emergency occurs when two trucks, one stolen and containing nuclear waste, crash in a tunnel in Idaho, threatening to explode and wipe out a nearby town. Donna asks Josh to ask the president for a special proclamation recognizing her favorite h.s. teacher. Bartlet can't oblige, but he comes up with a very uplifting consolation for Donna to let her teacher know how much she appreciated her. Episode title refers to James Bond's preference for "shaken, not stirred," which Bartlet insists results in a weak martini; this ties into Hoynes and Leo making the president aware that Hoynes is a recovering alcoholic, just as the w.w. staff is considering bumping him.

Toby falls prey to a practical joke by the rest of the staff, after which everyone but Leo takes off for the debate in San Diego. Sam makes a side trip to Newport Beach to explain to the congressional campaign manager of the late Horton Wilde why the campaign has to fold even though Wilde is still on the ballot; what Sam doesn't expect is a stalwart named Will Bailey who, determined to keep the ideas of the campaign alive, continues to hold campaign events and do door-to-door canvassing. In San Diego, a nervous w.w. staff readies itself to spin for the president, but when Bartlet and Richie go head to head in a unique debate format, Bartlet tears Richie apart on states' rights, education, taxes, etc., by being precisely the intellectual snob everyone had accused him of being and using it to his own advantage. Back in DC, Leo and Jordon Kendall meet with the Qu'mari ambassador to the U.N., and Leo warns Qu'mar to back off its campaign to charge Israel with the assassination of Defense Minister Abdul Shareef. After the debate, Sam returns to Newport to meet once more with Will at a bar, during which Sam makes a surprising offer.

A 15 year old boy needs a heart and lung transplant. He also happens to be the son of the Iranian Ayatollah who is not a supporter of the Bartlet Administration.

On his first day on the job, the new deputy counsel uncovers a trail of clues to a scandal that will end one person's career.

Press leaks lead to the revelation that former VP John Hoynes is about to release a tell-all book about the administration.

After spending months negotiating a difficult summit with China, Josh is dismayed to learn that the President accepted a flag symbolizing Taiwanese independence. Vice President Hoynes appears on television to promote his book and indicates a desire to return to politics. With the Iowa caucuses only a few months away, Vice President Russell and others begin positioning themselves to win the Democratic presidential nomination. President Bartlet finds tying his bow tie unexpectedly difficult.

On the same day that an anti-gay-marriage amendment is attached to the federal budget, an Internet rumor surfaces that C.J. is a lesbian. Josh and Toby attempt to kill the amendment without forcing the President to publicly take a position on this unwinnable issue. Congressman Santos considers Josh's proposition that he run for President despite having told his wife that he's done with politics. Donna begins her new job while Josh struggles to cope with her difficult replacement. Abby and C.J. meet with the President's doctors to decide how to adapt his schedule to the increasingly debilitating effect of multiple sclerosis.

Five days before the New Hampshire Democratic primary, the Santos campaign risks extinction as Matt has not been invited to the last debate. Josh proposes a number of strategies to get Santos into the debate, including deal-making, legal challenges, attack ads, and publicity stunts - but the Congressman is reluctant to play along. With Josh scrambling to keep the campaign alive, Santos calls in help from Washington to tune his message. Hoynes and Russell launch attack ads on each other's records, and Josh realizes that a desperate long-shot is needed to keep Santos in the race.

Hoynes and Russell are campaigning in New York, confident of their prospects in the California primary. Santos needs to do unexpectedly well in California in order to stay financially afloat; another third place finish will see his donors shift their money elsewhere, finishing his campaign. Santos's message of education and health care is overshadowed when California passes a law prohibiting drivers licenses for illegal immigrants. Despite the bill being widely supported by most voters, Matt cannot publicly endorse it as he's counting on the support of Latino voters, who expect him to denounce it.

WHO WILL BE THE DEMOCRATIC PRESIDENTIAL CANDIDATE? - It's the Democratic National Convention and the race to become the Democratic Presidential candidate has narrowed to three candidates: Russell, Baker and Santos. Also, Bartlet must wrestle with the decision to launch the super-secret defense shuttle to rescue the astronauts trapped at the space station and risk national security or let them die.

President Bartlet and his current and former staffers come together for Leo's funeral.