Dr. Robbins concludes that a woman covered with red blotches has not died of Ebola. In the autopsy, he learns that the woman is Julie Stern, who was recovering in the hotel from a cosmetic procedure. He also tells to Catherine that she had urine in her stomach and signs of heavy metal poisoning. Catherine and Nick interview her doctor, Tony Malaga, who owns an expensive clinic. When Dr. Robbins finds the same symptoms in the autopsy of Renita Loakes, they return to the clinic with a warrant to get their medical information. Meanwhile, Grissom, Sara, Greg and Capt. Brass investigate the death of Elliot Beckman, whose house was fumigated and his body was found inside. The exterminators tell them that the house was supposed to be empty when they released the gas.

The CSI team is called to help when Karen Mathews reports her son, Jesse, missing from a playground where he was playing on the swings. Witnesses report seeing a man with a blue baseball cap near the swings. Clues in the park bathroom include blood and the boy's underpants. The boy is eventually found in a store, accompanied by a woman with a man fitting the earlier description. But the couple with the boy claim that he is their son Adam, while Karen insists he is her missing son Jesse.