When Nikki wakes up, she sees the two criminals dead in her garage. She brings her son and finds a brand new Cadillac in her name and the bodies in the trunk, with instructions and a map to bury the corpses in the desert. Peter awakes in the hospital and his mother tells him that his father was depressed and committed suicide. When Peter decides to jump from the terrace of his building, his brother Nathan discloses that both can fly. Hiro is teleported to the Times Square and finds a comic book written by Isaac Mendez telling his saga. He goes to Isaac studio, finds him dead and is arrested by the police. A man pretending to be an exterminator bugs Mohinder's apartment, but he fights with the guy and is helped by his next door neighbor. In Los Angeles, the Police Officer Matt Parkman telepathically hears the voice of a child in a murder scene and is arrested as a suspect. Claire hides her heroic rescue in the fire and her seemingly evil adoptive father discloses her abilities in her stolen tape.

As the "Heroes" continue to test their newfound extraordinary abilities, Claire tries to maintain a normal social life when a romance with the football quarterback takes a tragic turn. While Hiro convinces his friend that they are destined to travel to America to save the world, a frightened Niki follows instructions from a mysterious, unknown source that directs her to the middle of the desert. Meanwhile, Nathan uses Peter's accident to propel his political campaign. The elusive Sylar is being hunted by both Matt and the FBI, as well as Suresh, whose father's journal leads to potential clues.

Suresh finally tracks down one of his father's fabled genetically advanced "supermen." In Las Vegas, Hiro's plan backfires when he cautiously turns time to his advantage at the gambling tables. Niki's mafia debtors use their leverage to their benefit in a more elaborate scheme, while Nathan pays a personal visit to a wealthy Vegas contributor to raise additional campaign funds. Following a tragic turn at a bonfire, Claire's uncanny healing abilities are put to the ultimate test, but according to Isaac's paintings, her future could be fraught with even more peril. Meanwhile, Matt's abilities are gauged by a pair of men who seem to know a great deal about people with special gifts.

Niki is questioned by police about her fugitive husband's whereabouts; Matt's relationship with his wife, Janice, benefits from his mind-reading abilities; Claire divulges her secret to her father; Hiro has a violent run-in with Las Vegas high rollers; Peter receives a life-changing message; and Mohinder contemplates leaving New York---and his father's research---behind.

As Homecoming approaches in Odessa, Claire's father makes an effort to save Claire's life. Peter, having tried to contact Hiro, flies to Texas in his effort to save the cheerleader. Hiro decided to head back in time in an effort to save the waitress, and Suresh can't get a dream out of his head and feels it has some answers about him and his father.

Claire Bennett is at home reading when the cheer leading captain walk in with a uniform and informs Claire that another cheerleader dropped out and the spot is hers if she wants it. Hiro Nakamura has traveled back in time to the Texas diner but realize he can't after she tells him she has a terminal disease. Nathan Petrelli and Peter Petrelli are preparing to take down their dad D.L. Hawkins and Niki Sanders are newly weds. Chandra Suresh has come to America to find and contact the people he thinks have taken an evolutionarily step. Sylar is the first but doesn't appear to have extraordinarily powers but then has the power to move things with his mind after he invites and kill another person on Chandra's list and then goes back to Chandra

When Hiro travels three years into the past, he has a second chance to save Charlie from the hands of Sylar. However, Samuel's presence serves to complicate Hiro's mission even further. Elsewhere, H.R.G.'s past with his Primatech partner is revealed.

Hiro's life hangs in the balance as his brain tumor worsens, prompting him to subconsciously deal with some of his past decisions. Meanwhile, Sylar pays Claire an unexpected visit to get answers as to why he isn't quite himself. Elsewhere, Samuel's plan to impress his long-lost love, Vanessa, takes a terrifying turn.