Three concurrent surgeries at the hospital push its staff to the limits. Determined to ease the pressure, Nic requests Jude for one of the operations, making Conrad jealous. Meanwhile, Dr. Lane Hunter sets out to discredit Nic's claims, Devon struggles with a patient who has an embarrassing problem and a charitable contributor comes to the hospital wanting to donate a lot of money to Dr. Lane's oncology program.

As Conrad battles a group of overly aggressive attending physicians on behalf of a patient with a mysterious chronic ailment, he also must face off against his father who has shown up at the hospital unannounced. When Mina goes out of her way to help a young man from her neighborhood who almost mugged her, Nic offers her assistance and discovers a secret that Mina has been keeping behind closed doors. While away from the hospital, Nic enlists the help of Devon to keep an eye on Lily, which leads him to an incredible find that has him questioning Dr. Lane's motives. Also, Renata's plans to poach a renowned surgeon from another hospital hit a standstill when Bell decides he doesn't agree with him.

Conrad turns to someone he thought he would never have to confront again to save Nic from being taking down by Lane.

Conrad's father, the new chairman of the board, wants his input in his discussions about Chastain's expenses; a sharp and sophisticated medical device rep inserts herself into the doctors' work to promote her products.

Nic and Conrad think about their history when they diagnose a husband and wife with mysterious symptoms.

Chastain is flooded with concert goers following a stampede at a music festival grounds that leaves many in need of doctors.

Halloween at Chastain proves to be just as spooky as ever when Conrad is tasked with diagnosing a young woman admitted to the hospital with extreme night terrors. Meanwhile, Devon faces his first Halloween in the ER, Nic panics over her decision to bring her newly sober sister to Mina's epic annual Halloween party and Bell finds an interesting way to make use of his new assistant.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

The surgeons are determined to shut down Quovadis after Henry Barnett almost loses his life due to a device malfunction. As Mina and Devon set out to find the truth, Bell, AJ and Conrad work to save the life of Chastain's favorite custodian, Simon. Meanwhile, one of Alec's old patients ends up in the ER, forcing him to question if he made the right choice to leave his old practice for Nic's clinic.

The surgeons work together to save the life of the Raptor's old mentor, Abe, who is their only inside source to Quovadis. Unfortunately, when Nic and Conrad take on a patient needing the hospital's only viable ECMO machine, they must decide between saving the life of Abe or saving the life of their younger, more stable patient. Meanwhile, Marshall puts himself in serious danger to help take down Gordon Page once and for all.

Chastain picks up the pieces after the fall out with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth. As Conrad and Alec team up to help a young gymnast experiencing mysterious symptoms, Nic focuses on her sister, who's back with their estranged father, Kyle, in tow. Meanwhile, Bell rushes to Kitt's aid when her ex-husband comes to the ER needing emergency surgery.

On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.

After being terminated from Chastain, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system, which causes Devon's new intern to agree to a procedure before weighing the risks. Meanwhile, Mina struggles with taking care of Adaku's baby and Bell's supplement company gets its big break.

Just when Derek's condition seems to be improving, a severe complication arises, causing Kitt to fear that he may be the latest victim of Cain's cover-up. When Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life. Meanwhile, Conrad fills in Marshall on the emergency situation facing the hospital and Mina and The Raptor work on saving the heart of a salsa dancer.

During the COVID-19 pandemic, the staff of Chastain does their best to treat the overwhelming number of patients that they face while also trying to protect their loved ones; Conrad and Nic get married.

Chastain is being dismantled, Doctors and surgeons are transferring and patients are panicking. Nic and Conrad announce they're going to be parents when another tragedy strikes.

With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain. Devon stays by Rose's side as she starts her clinical trial and things take a turn for the worse. Meanwhile, Kit is under pressure to bring Chastain out of debt.

On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything. Devon and Leela stumble upon an apartment fire, where they assist in getting victims safely to Chastain and Leela gets a chance to prove her skills to Raptor. Meanwhile, Jake and his husband deal with the complications of Sammie's health, as they prepare to become more permanent fixtures in her life, and both Raptor and Rose receive exciting news.

The wait is over as Conrad and Nic welcome the arrival of their baby girl. Meanwhile, Raptor's life begins to fall apart and he is forced to turn to Cain for help. Also, Devon and Bell work together on a complicated surgery that may allow them to save multiple lives. Then, Kit tries to deal with the moral repercussions of financially saving Chastain.

A cyberattack sends the hospital into a tailspin and Kit has to decide whether to pay the ransom. Conrad has to balance work with being a new dad. Devon and Leela debate where their relationship is going.

An accident brings a familiar patient into the ER, the doctors must face the reality of how to proceed with the best care while questioning every decision. The Raptor and Leela treat a patient dealing the long-term effects of COVID

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell's mentor.

When Billie's past mistakes are exposed, the team struggles to find a way to support her. The nursing shortage hits Chastain. A simple cleaning job goes horribly awry.

After a teenage boy is taken into Chastain for falling unconscious from a suspicious pill, Conrad takes action to find the boy's brother before he meets the same fate; Dr. Bell deals with being served court papers from a former patient.