King Henry VIII, the young and ambitious monarch of England, prepares for war with France but is dissuaded by the diplomatic manipulation of his powerful Lord Chancellor, Cardinal Wolsey, who proposes that the King sponsor a "Treaty of Universal Peace." The harmony of the King's domestic affairs is threatened, however, when he discovers that Elizabeth Blount, the young and beautiful lady-in-waiting to his Queen, Katherine of Aragon, is pregnant with his child.

Henry and his court look to sign the treaty with France, though tempers of both kings flare up at the summit. Meanwhile, Henry takes on a new mistress named Mary Boleyn, though he soon tires of her and Mary's sister, Anne, is summoned to the court.

The Archbishop's capitulation to Henry results in Thomas More's resignation and a triumphal trip by Henry to France to show off his new queen to Francis.

After Henry breaks all ties with the church and marries Anne, the Pope threatens him with excommunication and authorizes Anne's assassination.

After princess Elisabeth's baptism, Henry orders Thomas Cromwell to draw up a bill of succession favoring his and Ann's offspring, to be accepted by an oath from all subjects. The affront to the imperialist party is maximized by making princess Mary a lowly lady in waiting to her half-sister, yet the French King still refuses openly to recognize the new Queen. Ann orders her rival lady Eleanor Luke eliminated, by false charges of jewel theft. Tired of Henry's schismatic obstinacy, Pope Paul III makes the loyal, hence jailed bishop Fisher a cardinal, Henry orders his beheading. Thomas More can no longer support his entire family, yet answers Cromwell's questions with Henry's own pamphlet arguing for papal supremacy by divine right. At her father Thomas Boleyn's suggestion only an ambitious mistress is a problematic rival, Ann urges Margaret 'Madge' Sheldon to 'succeed' Eleanor. Thomas More refuses to take the oath as phrased, while accepting he succession, landing him in the Tower.

Fisher and More continue to resist the coercion to take the oath and pay with their lives as Henry's ardor toward Anne subsides after her miscarriage.