The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Ethan finds himself at odds with Natalie and Sharon as he treats a teenage mother who abandoned her newborn baby in an alley.

Connor is forced to confront his past when he takes on the case of a close family friend who's been impaled by glass shards.

In the aftermath of a movie theater shooting, the doctors work to treat the victims while Sharon tries to keep the press at bay.

As Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.

Sharon is visited by the Department of Homeland Security regarding two airplane stowaways who are brought to the hospital with major injuries.

Sharon must decide whether to put her job on the line for a patient in need.

A Saudi prince arrives for a surgical procedure, while Dr. Manning returns from maternity leave and treats a teen with a long history of medical issues.

Dr. Halstead jeopardizes his career when he goes against a family's orders and revives a terminally ill cancer patient.

Doctors Rhodes and Downey set aside their differences to operate on a 9/11 hero with pulmonary fibrosis.

Doctors Rhodes and Choi disagree over a dying patient's request.

Nurse Lockwood is arrested for refusing to take blood from a suspected DUI patient without his consent.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Doctors Manning and Charles have a 16-year-old patient with abdominal pain who refuses to take drugs, while Dr. Halstead has a patient who turns out to be an old high school classmate.

Doctors Rhodes and Downey have a disagreement over a patient's emergency heart surgery.

April and Dr. Halstead treat an alcoholic homeless man with a broken leg.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

The doctors of Chicago Med experience various changes.

Dr. Choi mentors a Navy corpsman, while two cases involving sick babies may have a connection.

Family secrets are revealed when Maggie's sister visits.

Dr. Charles' daughter deals with cases of a rare infection when she joins the epidemiology department.

An accident at the Chicago Marathon puts the medical personnel into action.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.

Sharon's childhood sweetheart arrives at the hospital, while Halstead tries to get his finances in order.

Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.

April discovers her TB medication may lead to further problems, while Dr. Choi learns an important lesson as he treats two MMA fighters who are in bad shape.

Maggie faces her past when the police officer who arrested her is brought into Chicago Med with a serious injury.

Dr. Reese endures a long night on the graveyard shift, while Dr, Rhodes is asked to work on a most unusual patient.

Dr. Manning and Dr. Charles treat a teenage girl with a rapidly changing set of symptoms that has everyone perplexed. Dr. Choi and medical student Jeff Clark encounter a 19 year-old tough guy who is brought into the hospital in severe distress. Once they establish the cause of the pain, the situation quickly turns dangerous and a resolved Dr. Reese does her best to help. Elsewhere, Dr. Latham makes a big admission to Dr. Rhodes while Dr. Halstead must deal with a difficult case that is further complicated by Dr. Stohl, who has a camera crew following him around to shoot a promotional video spotlighting the hospital.

Dr. Latham is talked into going with Dr. Rhodes on a medical trip out of town; an 8-year-old cancer patient wants to give up; a woman with a personality disorder makes a case complicated.

The doctors and nurses of Chicago Med brace for an influx of patients when a multi-vehicle accident during a blizzard puts the hospital in scramble mode.

Dr. Rhodes is under pressure to keep a trauma patient alive and April befriends a patient with a failing heart.

Dr. Manning deals with treating a comatose young woman who's pregnant.

Choi and Halstead argue over how to treat a patient with stroke symptoms while Manning treats a boy who fell in the river and watches the family drama unfold.

Will's former teacher has a life-threatening disease while Rhodes argues with the father of a young patient over a risky procedure.

The hospital computer system is shut down by a hacker demanding a ransom payment.

The doctors deal with trying family matters.

Rhodes tries to save a mother who's determined to help her daughter beat cancer.

Dr. Rhodes clashes with Dr. Charles and other medical staff over how to treat Dr. Charles's daughter Robin.

Robin returns to the hospital with more complications; Rhodes faces competition from a new doctor.

The doctors of Chicago Med attempt to bring the person who shot Dr. Charles to justice.

Dr. Manning goes to extreme measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake. Dr. Charles and Dr. Reese continue to disagree about their psych patients.

Financial concerns from the board cause tension between Chief Goodwin and her staff. Goodwin is faced with some difficult choices. Meanwhile, Dr. Charles and Dr. Reese deal with a patient who believes there is something living inside of his stomach. Dr. Choi and Halstead work together on a strange case of their own.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps Bert understand Lyla's sickness.

Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning's son to like him.

After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor and world renowned surgeon, Dr. Marvin Jaffrey. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.

Dr. Manning hits her head while helping the victim of a drive-by shooting; Dr. Rhodes learns surprising information about the woman he dated.

Dr. Choi enlists April's help to figure out how a neighbor got stabbed; Noah misdiagnoses a patient.

Dr. Manning and Dr. Choi help a pregnant teen deliver her baby at a homeless encampment.

Halstead and Manning are at odds when a woman makes a decision about her vegetative adult son; Rhodes goes behind Bekker's to get his patient to the top of the transplant list; a woman in the waiting room won't wake up.

Med goes on lock-down when a baby is abducted; Rhodes must figure out how to get into the operating room to help with an open-heart surgery; Manning and Halstead disagree on how a patient should be treated.

A mother brings in her daughter claiming she's possessed; Rhodes and Bekker must save a pair of conjoined twins; Halstead tries to get Manning's attention; Maggie weighs her options.

Dr. Bekker takes the lead on a surgery, then takes the heat when something goes wrong.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to handle the boy's parents; Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

After a shooting occurs during a block party at a local park, Med is overrun with victims that stretch the hospital and staff to its limits.

Dr. Manning rushes to save a young boy with a life threatening case of the flu; April suspects Dr. Choi's sister stole opioid pain killers; Dr. Rhodes and Dr. Bekker disagree over the best treatment for a cardiac patient who is 21 weeks pregnant.

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information concerning Dr. Reese's father.

Goodwin clashes with new hospital COO Gwen Garrett while April questions whether Ethan's sister is using drugs again; Charles confronts his past actions.

Dr. Charles' daughter deals with cases of a rare infection when she joins the epidemiology department.

Rhodes tries to save a mother who's determined to help her daughter beat cancer.

Doctors Rhodes and Choi disagree over a dying patient's request.

Dr. Reese endures a long night on the graveyard shift, while Dr, Rhodes is asked to work on a most unusual patient.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

The doctors of Chicago Med attempt to bring the person who shot Dr. Charles to justice.

Sharon's childhood sweetheart arrives at the hospital, while Halstead tries to get his finances in order.

Doctors Rhodes and Downey set aside their differences to operate on a 9/11 hero with pulmonary fibrosis.

The doctors of Chicago Med experience various changes.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.