Finally ready to work again after giving birth to her baby, Dr. Mike must lead a rescue party when Sully and Cloud Dancing are among the passengers on a train that has been overtaken by robbers and wrecked. Sully had negotiated Cloud Dancing's release from Army detention, and the two were taking the train to Colorado Springs when a gang of thieves derailed the train in an effort to rob it. Meanwhile, Dr. Mike must again face the prejudice against women doctors when she finds that the townspeople have become used to being treated by young Dr. Andrew Cook who filled in for her while she was on maternity leave. For his part, Andrew has become reluctant to return the practice to Dr. Mike and go back to Boston, as originally agreed.

General Wooden is injured by dog soldiers and dies. Daniel talks with Sgt. McKay and the non-violent Indians are let free. Hank takes over as sheriff temporarily. Daniel runs for sheriff and wins. Sully and Cloud Dancing work for peace.