Susan Lewis' boyfriend Div Cvetic, a psychiatric resident at County General, seems to be under a great deal of stress regularly lashing out at everyone. Doug Ross takes over for Mark Greene who takes a day off to be with his wife. He has a hard time keeping up with all the paperwork. John Carter is increasingly frustrated with Peter Benton who never seems to invite him to participate in surgeries. Benton learns the result of the fellowship he applied for and his mother shows up in the ER with a sprained ankle. Carol Hathaway treats a patient who was raped. A new ER aide, Bob, start work.

Carol Hathaway faces an ethical dilemma when a patient admits that he, and not his friend, was driving the car that ran a red light and killed a pedestrian. She decides to tell Tag about kissing Doug Ross. It's Thanksgiving and the doctors treat an animal rights activist who was attacked by the turkey he was trying to save. Doug Ross is going to the Bahamas with Linda Farrell and he is very much feeling like a kept man. Carter has to treat a transgender woman who has now reached an age where she can no longer pass as a woman. Carter's indifference is the final straw. Susan Lewis continues to worry about Div Cvetic, whose condition seems to be worsening.

The ER staff's slow snow day becomes chaotically hectic when the casualties of a 40 car traffic accident flood in.

It's Christmas-time and the expected range of emotions is to be found among the ER staffers. Susan Lewis treats a middle-aged woman who is overjoyed at finally getting pregnant. Susan is also shocked to hear that her boyfriend Div Cvetic has quit his job and moved out of his apartment. Mark Greene treats a young drowning victim. Doug Ross takes Greene's advice and decides to tell Carol Hathaway that he loves her; unfortunately he chooses to do so at her engagement party. Peter Benton jumps the gun and arranges for transplant teams to harvest an accident victims organs but the man's wife is now refusing to give consent. Susan's sister Chloe announces that she is pregnant.

Susan Lewis has a run-in with Dr. Jack Kayson, the cardiology attending, when he accuses her of not providing him with all necessary information on a patient who subsequently died. He makes it very clear that Susan will bear all responsibility for his death. Her sister Chloe informs her that she and her boyfriend are moving to Texas. John Carter is still frustrated by Peter Benton's apparent lack of interest in teaching him anything but a new go for it attitude leads to an invitation to assist in a surgical procedure. Benton's sister suggests to him that the time has come for them to put their mother in a care home.

Dr. Greene gets offered a new job by Morgenstern.

Dr. Greene is still haunted by the death of Jodi O'Brien and isn't sure he can function as a doctor. At Susan's urging, he takes the night off but unfortunately for him, the new head of the ER Dr. 'Wild Willy' Swift arrives unannounced. Susan impresses Swift with her handling of many cases on a busy night. She also has to deal with the case of a young man who has had the hiccups for two days but may in fact be suffering from something far more serious. Nurse Hathaway and fiancée Tag are still working out the details of their wedding. Peter Benton's mother is still hospitalized and he will not accept that her age and her injuries mean that she will need permanent nursing care. Dr. Ross is now dating Diane Leeds. John Carter and Deb Chen's attempts at oneupmanship is starting to take on ridiculous proportions.

It's Weaver's first day and she doesn't exactly make a lot of friends. Carol rides along with the paramedics.