April's visiting sisters get on her nerves; when Matthew and Jackson witness an accident, they must work together; Callie and Arizona work on their relationship.
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- Dr. April Kepner
- Dr. Alex Karev
- Dr. Jackson Avery
- Dr. Cristina Yang
- Dr. Meredith Grey
- Dr. Derek Shepherd
- Dr. Arizona Robbins
- Dr. Richard Webber
- Dr. Callie Torres
- Dr. Jo Wilson
- Dr. Miranda Bailey
- Matthew Taylor
- Dr. Owen Hunt
- Dr. Stephanie Edwards
- Dr. Shane Ross
- Dr. Leah Murphy
- Jimmy Evans
- Dr. Alma
- Becca McMurdo
- John McMurdo
- Kimmie Kepner
- Alice Kepner
- Libby Kepner
- Dr. Hudson
- Ashley Glazier
- Don Glazier
- Leo Davis
- Tim Bowman
- Nurse
- Nurse