King Henry VIII, the young and ambitious monarch of England, prepares for war with France but is dissuaded by the diplomatic manipulation of his powerful Lord Chancellor, Cardinal Wolsey, who proposes that the King sponsor a "Treaty of Universal Peace." The harmony of the King's domestic affairs is threatened, however, when he discovers that Elizabeth Blount, the young and beautiful lady-in-waiting to his Queen, Katherine of Aragon, is pregnant with his child.

The King asks Charles to escort his sister, Margaret, to her betrothed and promotes him to Duke of Suffolk. The envoys from the Holy Roman-Emperor meet with Cardinal Wolsey and determine how to cement the treaty between the two nations. Anne catches the King's notice in a play. The Emperor is invited to the King's court. It is learned that the King of France knows of the treaty talks- and the Cardinal is quick to find a scapegoat. We learn more of why Anne's father and uncle want her to seduce the King.

Sir William Compton is diagnosed on his Warwickshire estate with highly contagious 'sweating sickness', the physician bleeds his back- death comes swift, his body is burned before burial, Thomas Tallis breaks his lute on the fresh grave, then courts Joan Larke. The Cardinal flatters Ann and announces the alliance with France against the emperor is a fact, while he sends lawyers Stephen Gardiner and Foxe to pope Clement VII in Orvieto, requesting an annulment of the royal marriage to Catherine, if necessary by threats, while the emperor demands confirmation. The duke of Norfolk is removed from court. Just after the arrival of the new French ambassador, who promises French troops will drive the emperor out of Italy soon, the epidemic and utter panic reach London, even the royal court, where Henry tries every remedy, including working up a natural sweat, ultimately flees like most before him. The pope appoints cardinal Campeggio as legate to constitute a divorce court with Wolsey after the plague. Moore tells his daughter Lutheranism is a far worse danger then the plague, in all Europe. Unlike tens of thousands, Anne Boleyn and Wolsey survive, the plague recedes, the papal legate arrives as court reassembles, Tallis conducts a mass of thanks.

Cardinal Campeggio's long awaited papal legation has arrived at court to decide with colleague-cardinal Thomas Wolsey on the royal request for divorce, claiming Catherine's first marriage to Henry's late elder brother nullified his. When Campeggio learns the king won't yield, he suggests an alternative: the queen could retire to a monastery, but only voluntarily, which she refuses, swearing in confessional she came as a virgin to Henry. Thomas Tallis proposes to his late lover Joan's sister Jane. Under Anne Boleyn's love spell, Henry sends bishops to tells the queen she's suspected of hating and conspiring against him, and grows angry at Wolsey's failure to persuade or threaten Campeggio, even sends Charles Brandon to Paris to question the French king Francis I about the true intentions of the emperor, pope and cardinal. Brandon also confirms to father Thomas Boleyn's party the time may be ripe to bring Wolsey down. When the legatine court finally assembles, the king states his case personally as a matter of justice, allegedly after 'his conscience' finally stopped him from keeping silent out of love for the queen. Wolsey simply brushes aside the queen's objections to the competence and objectivity of the court. After imploring justice and appealing to Henry kneeling at his feet, Catherine walks out, to public acclaim, royal fury and Wolsey's despair.