Brenda feels the clock is ticking and wants to have a baby sooner rather than later. Nate wants to think about it for a while. A lunch with her mother Margaret doesn't go particularly well - Margaret is rushed to the hospital. The event does give Brenda and Billy a chance to see each other again. George feels they should be preparing for whatever catastrophe may befall mankind. Ruth tells him of the old bomb shelter and he thinks it's just perfect. Claire's latest project gets raves from Billy and several of her classmates but she reacts badly when Russell claims to have originated the concept with her. She's thrilled though when she gets the opportunity display some of her work at a show. David learns that the man whose ear he's bitten is suing him for $500,000. There's one way he can get out of it but it involves Keith. At the funeral home, Rico and Nate deal with a particularly tragic case when four members of the Gorodetsky family - parents and two children - are killed in a car accident leaving only their eldest son to deal with it all. Nate is forced to admit to Lisa's sister Barb that he buried her in the desert.

George's infatuation with impending disaster is causing him nightmares. His daughter Maggie joins him and Ruth for dinner and she has a lot of stories about her dad. Later, Ruth is quite concerned when she finds George talking by himself to an imaginary person. Claire's showing of her work is a huge success but she ignores her friends in the process. Nate is stressing over Barb's threat to take Maya away from him. He learns more about the circumstances of Lisa's death, leading to another tragedy. David hopes that if he faces his attacker, who is now in prison, he will feel liberated. It doesn't quite work out that way. Keith gets an interesting offer from Roger, who had promised to drop his lawsuit against Dave in return for sex.

While trying to reach the newspaper on the sidewalk, Samuel Wayne Hoviak, who was the best high-school friend of Nate, falls and his truck run over him. In the funeral service, Nate meets their other former best friend, Tom Wheeler; they recall their adolescence and realize that they are getting up. The bitter and deranged Ruth has no patience with George, and they receive his daughter Maggie. David proposes Claire to donate her eggs for the baby of his own with Keith, but she refuses. Claire feels her art rejected by the owner of a gallery and Billy misses his former personality. Rico dates Sharon and does not understand her hint that she does not want to see him again. Brenda begins an internship in a free clinic and does not support her first day, seeking Margaret's influence to help her to find a better place to work.