The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

In the aftermath of a movie theater shooting, the doctors work to treat the victims while Sharon tries to keep the press at bay.

As Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.

Doctors Rhodes and Choi disagree over a dying patient's request.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

The doctors of Chicago Med experience various changes.

Dr. Reese endures a long night on the graveyard shift, while Dr, Rhodes is asked to work on a most unusual patient.

Dr. Manning and Dr. Charles treat a teenage girl with a rapidly changing set of symptoms that has everyone perplexed. Dr. Choi and medical student Jeff Clark encounter a 19 year-old tough guy who is brought into the hospital in severe distress. Once they establish the cause of the pain, the situation quickly turns dangerous and a resolved Dr. Reese does her best to help. Elsewhere, Dr. Latham makes a big admission to Dr. Rhodes while Dr. Halstead must deal with a difficult case that is further complicated by Dr. Stohl, who has a camera crew following him around to shoot a promotional video spotlighting the hospital.

Dr. Rhodes is under pressure to keep a trauma patient alive and April befriends a patient with a failing heart.

Dr. Manning goes to extreme measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake. Dr. Charles and Dr. Reese continue to disagree about their psych patients.

Dr. Manning and Dr. Choi help a pregnant teen deliver her baby at a homeless encampment.

Halstead and Manning are at odds when a woman makes a decision about her vegetative adult son; Rhodes goes behind Bekker's to get his patient to the top of the transplant list; a woman in the waiting room won't wake up.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to handle the boy's parents; Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

A sick boy is brought to the hospital, forcing Ethan to face a tough decision that grows into a complicated and dangerous situation.

Will must lie to Natalie; Ethan and April uncover compromising information about Emily's boyfriend; Ava isn't sure what to do with a patient who doesn't want treatment.

Dr. Halstead rushes to rescue Dr. Manning from a chopper crash. Drama between Dr. Rhodes and Dr. Bekker boils over. Dr. Charles and Dr. Choi work to help a patient with their addiction. April helps Elsa deal with losing her first patient.

Will and Natalie battle for their lives after a car accident. An investigation is launched following the suspicious death of Cornelius Rhodes. Maggie receives life-changing news. Dr. Charles cuts his honeymoon short to tend to a patient.

A power outage at Med puts multiple patients at risk and tests the skills of the staff and their enthusiastic med students; Natalie returns following her traumatic brain injury; Ethan and April wonder if a family is in their future.

After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

Marking the series milestone 100th episode, Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend to a police officer with a mysterious gunshot wound to the abdomen. Relationships are put to the test as secrets are revealed.

Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer's is brought into the E.D. Maggie and Ben become concerned when one of Ben's students is admitted. Dr. Manning and Dr. Marcel treat a terminally ill patient and disagree over the best course of action.

Dr. Charles evaluates a 15-year old who is brought into the E.D. after an apparent fall off an overpass. Will sides with Dr. Asher on a risky treatment plan. Tensions run high between Dr. Choi and Dr. Marcel.

In the season six premiere, the entire staff at Chicago Med adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

The outcome of Will's investigation weighs heavily on his mind as he and Dylan work to save a four-month-old patient. Stevie and Vanessa both struggle to keep their secrets. Crockett and Blake work with Abrams to save a patient in need of a liver transplant.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.