As Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.

A Saudi prince arrives for a surgical procedure, while Dr. Manning returns from maternity leave and treats a teen with a long history of medical issues.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

The doctors of Chicago Med experience various changes.

Dr. Choi mentors a Navy corpsman, while two cases involving sick babies may have a connection.

An accident at the Chicago Marathon puts the medical personnel into action.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.

Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.

Maggie faces her past when the police officer who arrested her is brought into Chicago Med with a serious injury.

The hospital computer system is shut down by a hacker demanding a ransom payment.

Robin returns to the hospital with more complications; Rhodes faces competition from a new doctor.

Financial concerns from the board cause tension between Chief Goodwin and her staff. Goodwin is faced with some difficult choices. Meanwhile, Dr. Charles and Dr. Reese deal with a patient who believes there is something living inside of his stomach. Dr. Choi and Halstead work together on a strange case of their own.

A sick boy is brought to the hospital, forcing Ethan to face a tough decision that grows into a complicated and dangerous situation.

As Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.

A Saudi prince arrives for a surgical procedure, while Dr. Manning returns from maternity leave and treats a teen with a long history of medical issues.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

Dr. Choi mentors a Navy corpsman, while two cases involving sick babies may have a connection.

An accident at the Chicago Marathon puts the medical personnel into action.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.