Henry Darius, a man who killed several women in New York, claims that he also killed a woman in Miami and offers to show them where he buried her. The plane transporting him suddenly has to make an emergency landing and Dairus escapes. He kills some people to get their car. Horatio learns that the plane was sabotaged and he thinks Darius had a hand in it. Horatio sends for New York Detective Mac Taylor who was the one who caught Darius. Horatio decides to look at the woman's disappearance again and discovers that the husband didn't tell him some things that could have helped him find his wife. Darius continues to go on a killing spree and Horatio learns that Darius is not the killer, so he has to find out how Darius knew about the woman.

During an early morning trip to the bank, Delko ends up witnessing a robbery and fatally shooting one of the suspects. As the investigation progresses, Wolfe realizes that the robbers are trying to replicate a violent video game.

Horatio and his team investigate a double murder at a concert, but unraveling the mystery becomes difficult when leads take them in two directions: the Mala Noche gang, and a pharmaceutical company.