H.R.G. hosts a non-traditional Thanksgiving dinner by inviting Claire over at his apartment for dinner. But the dinner becomes more awkward and uncomfortable when Noah invites his former co-worker Lauren, while Noah's ex-wife, Sandra, also shows up with her newest beau, a younger man named Doug Douglas, whom like her also has a small dog fetish. Claire is also conflicted about where she wants to be, in which Noah invites over Gretchen to try to lift up her spirits. Meanwhile, the Petrelli family gets a surprise guest at their table when Sylar shows up having reclaimed Nathan's body and holds both Peter and Angela at his mercy. Elsewhere, Samuel continues to hold Hiro hostage as part of some grand master plan, as Lydia goes to Hiro in search of the truth about Samuel.

H.R.G. is greeted by some unexpected visitors and Samuel's grand plan begins to come to fruition. Meanwhile, Peter struggles to accept the truth and takes extreme measures to get what he wants. Elsewhere, Claire's journey leads her to an unexpected destination.

Samuel goes off and tries to bring Emma into the fold by manipulating her about how special her sight-of-sound powers are, while back at the Sullivan Brothers Carnival, Claire becomes more suspicious about Samuel's intentions and deals with not only Samuel's right hand, Replicating Man, Eli, but also the Puppet Master Eric Doyle. A delirium-stricken Hiro returns to Japan and tries to convince Ando in code-talk to help rescue Mohinder from a lunatic asylum in Florida where Hiro forcibly placed him for protection from Samuel.

H.R.G. recruits Matt to help him take down Samuel, as they use his long-lost love, Vanessa, to lure him to them, but Samuel has his own plans for Vanessa in the works. Meanwhile, Hiro and Ando go to extreme lengths to save Dr. Suresh. Elsewhere, Peter's introduction of Emma to his mother brings forth visions of a very grim future.

Hiro's life hangs in the balance as his brain tumor worsens, prompting him to subconsciously deal with some of his past decisions. Meanwhile, Sylar pays Claire an unexpected visit to get answers as to why he isn't quite himself. Elsewhere, Samuel's plan to impress his long-lost love, Vanessa, takes a terrifying turn.