Stripped of everything, the 48 survivors scavenge what they can from the plane for their survival. Some panic. Some pin their hopes on rescue. A few find inner strength they never knew they had-like Kate who, with no medical training, suddenly finds herself suturing the doctor's wounds. The band of friends, family, enemies and strangers must work together against the cruel weather and harsh terrain. But the intense howls of mysterious creatures stalking the jungle fill them all with fear. Fortunately, thanks to the calm leadership of quick-thinking Jack and level-headed Kate, they have hope. But even heroes have secrets, as the survivors will come to learn.

The castaways on the raft run into unexpected trouble. Meanwhile, the remaining islanders attempt to blow open the hatch. Flashbacks continue to show the survivor's final moments before boarding their fateful flight.

A parallel universe, in which the crash never happened, is revealed as an aftermath of the bomb's detonation. Meanwhile, Sawyer blames Jack for the loss of Juliet and the true identity of the monster is revealed.