Don continues to conceal his complicated personal life, even in the face of Roger's invitation to open up.

The Agency is looking to land an advertising contract to promote tourism to Israel. Don and his team try to come up with a theme but know so little about the country that they're stumped. So Don calls Rachel Menken to see if she has any ideas. Roger Sterling is getting tired of sneaking around with Joan Holloway and suggests she should get her own apartment but she knows better. Peggy comes up with an advertising concept during a testing session for a new line of lipsticks and she's subsequently asked to write copy.

It's Labor Day weekend and most of the men are sending their wives away for a few days. Don Draper's wife Betty is dreading the thought, as her father and his new girlfriend, whom she detests, will be staying with them. With the election approaching, the team at Sterling Cooper is gloomy since the Nixon campaign has not been following their advice. Roger Sterling was hoping to spend Friday night with Joan Holloway but having just seen the movie Piso de soltero (1960), she is feeling a bit used. She plans a night on the town with her old college friend who has some surprising information for her. Don and Roger invite twin sisters from a casting call to join them for a drink but things go badly for Roger who suffers a serious heart attack. After the incident Don ends up spending the night with Rachel Menken where he reveals a lot of his inner self.

Peggy is given the opportunity to write copy for a new weight loss device that everyone knows is useless. She finds an interesting use for it, however. Afraid of losing the Lucky Strike cigarette account, Bert Cooper gets Roger Sterling to come in for a one-hour meeting but he has another attack. Don Draper becomes a partner and takes over for his friend Roger, but some of the ad men are sharpening their resumes nonetheless. Pete Campbell wants a promotion but Draper doesn't seem too interested. Pete sneaks into Don's office and takes home a parcel sent by Adam addressed to Don that the mail room boy comes to deliver.

Freddy and Ken take a client out to lunch who stirs Roger Sterling's heart.

Betty becomes suspicious that Don is having an affair after her conversation with Jimmy Barrett, Joan helps out in the television department, and Peggy helps the church with a dance flyer.

Don checks in to a hotel after his separation from Betty. Back at the office, he is forced to get rid of Freddy against his will because of his drinking problem.

Don is brought in to save the day for a P.R. campaign involving the building of the new Madison Square Garden, only to have the rug pulled out from under him. At home, Betty argues with her brother over how to care for their sick father.

On the weekend of the John F. Kennedy assassination, Pete finds out that he lost the promotion to Cosgrove, Roger Sterling's daughter's wedding goes off as planned, and Betty musters up the courage to respond to Don's confessions.

Don gets a visit from the in-laws and his children just as he's about to receive a prestigious award and tries to save the Heinz account. Meanwhile, Peggy and her boyfriend take the next step in their relationship.

Don and Megan take a trip to Hawaii for the holidays, Sally's friend visits the Francis family, a comedian torpedoes Peggy's Super Bowl ad campaign, and Roger gets some bad news about his mother.

Don strikes up a friendship with the surgeon in his building, Peggy tries to save her campaign, Roger makes a scene at his mother's funeral, and Betty goes to Manhattan to find Sally's friend.

Don returns to work, but quickly falls off the wagon after learning that he's been assigned to Peggy. Meanwhile, Roger and his ex-wife go to a commune to rescue their daughter, who has abandoned her child.

Don and Peggy prepare to pitch to Burger Chef, one day after the Apollo Moon Landing. Meanwhile, a power struggle in the firm between Sterling and Cutler leaves Don's future hanging in the balance.