Simone makes contact with Ferdinand Hollie, an old informant, who wants to help him capture a pair of Colombian drug dealers who killed a young girl with their crossfire. But Hollie, a drug addict who is HIV-positive, has his own agenda to rob the Colombians. Meanwhile, Russell is paired with Sgt. Ray Kahlins, a "blowhard" from the federal anti-drug unit who is more interested in collecting overtime pay than catching a separate pair of drug dealers during a stake out. But Kahlins' brash tactics and disrespect for Simone and his informant Hollie, put both cases at risk. Also, Medavoy and Martinez investigate the murder of a Santería priest found in a local sewer and try to link a parole officer and a recent parolee to the crime.

Simone and Sipowicz look into the shooting of two women (one of whom was killed) who were raped by a group of men in an apartment owned by a former crack dealer, named Jamal, who was crippled in a previous shooting incident. Sipowicz confides in Simone about his medical condition when Simone sees Sipowicz's doctor pull him aside and talk to him confidentially. Meanwhile, Kirkendall, Russell and Medavoy investigate a shooting at a clinic. When they get a woman suspect into custody, a security guard from the clinic who was her secret admirer comes to the precinct demanding she get a second chance.