The West Wing staffers are introduced as each learns via phone or pager that the President was in a cycling accident. Josh faces the possible loss of his job after an on-air insult of a political opponent, which Toby tries to prevent by having Josh make a personal apology. Sam's fling the previous night with Laurie, who unbeknownst to Sam is a call girl, puts him in hot water, which he compounds when ineptly lecturing a class of 4th-graders about the White House and then asking their teacher which child is Leo's daughter. Leo must deal with the fallout from Josh's blunder, as well as 137 Cuban refugees who escaped on rafts and are seeking asylum. The president walks in during Josh's apology, recites the First Commandment, and lambastes three Christian pols for not denouncing a fringe group.

In the first of several episodes throughout the series' run that portrays ordinary Americans and how they interact with and ultimately affect the W.H., an Ohio middle school social studies teacher, a widower who has recently filled the brief remaining term of his late wife in the House, joins two other reps to meet with Toby and Mandy about changes to unfair rules in the U.S. Census written into the latest federal budget. The other two, career politicians, are completely resistant to the changes, but Mr. Willis is swayed by a potent argument Toby makes regarding "strict constructionism" (generally conservative and libertarian belief that the U.S. Constitution is not a living document, and must be followed as written, unless officially amended through standard 38-state ratification) and the 14th Amendment. Toby is impressed with the man and his open-mindedness. Elsewhere, Sam tutors C.J. on the finer points of the census. Late in the episode, the staff meets for a late-night poker party.

A crucial banking bill is at risk when political rivals of environmentally sensitive President Bartlet attach a land-use rider to it that would allow strip-mining some of the Montana wilderness. C.J. tries to stamp out rumors that the Chief Executive chastised the Vice President during a cabinet meeting. An overworked Leo isn't too keen on his independent daughter Mallory dating the handsome Sam. C.J. continues to fend-off the romantic charms of a perceptive reporter with a knack for sniffing out juicy stories. Former lovers Mandy and Josh clash over the administration's attempt to jettison the land-use rider that might also ruin passage of the more important banking bill.

When the President collapses on the eve of his State of the Union, it's diagnosed as the flu. But when the First Lady cancels a trip and rushes home to look after him, Leo suspects the first family is hiding something about Bartlett's medical condition.

The morning after Mendoza's confirmation, various staff members are brought back to earth by difficult meetings.

The President and NASA plan a TV event for a probe's landing on Mars; satellite photographs show a suspicious-looking fire in Russia; Leo asks Toby and Josh to decide on the next postage stamp; Sam and C.J. have personal reasons for not wanting to accompany the President to a concert.

Donna teaches Toby and Josh an important lesson as their trek homeward continues; Sam staffs the President in Josh's absence and welcomes an old friend home; Bartlet hires a secretary and C.J. finds a Big Brother for Anthony; the situation in Qumar continues to escalate; Bartlet gets spooked by a photo op as the Dow continues its dive; and a pipe bomb kills 44 students at a Midwest university swim meet.

Bartlet travels with former presidents Newman and Walken aboard Air Force One to the funeral of another former president. Meanwhile, Leo sits in the situation room dealing with demonstrations that are wracking Saudi Arabia and threatening to topple the royal family and CJ tries to deal with rumors of military mind control experiments. On board the plane, Toby tries to write Bartlet's eulogy as the crisis in Saudi Arabia grows worse.

Leo is found in the woods and rushed to the hospital; the staff struggle to hold the peace deal together without a Chief of Staff; the President neglects his duties out of loyalty and guilt towards Leo; Donna arrives back in the USA.

President Bartlet and his current and former staffers come together for Leo's funeral.

Santos and his staff prepare for the inauguration as Bartlet and his team look back on their years in the White House.