Comments made by Surgeon General Dr. Millicent Griffith concerning the medical effects of marijuana appear to reverse the President's stance on legalizing the drug.

Magicians Penn and Teller give a controversial performance at Zoey's birthday party in the White House that threatens to drown out the news of the impending China trip. President Bartlet goes to New Orleans on his way to China after unexpectedly requesting briefings be postponed until they are in the air. Josh tries to decide which Democratic presidential candidate he wants to support, and is alarmed that Bartlet wants to appoint California Republican Senator Arnold Vinick to be Ambassador to the United Nations.

President Bartet's attack of multiple sclerosis requires hasty reorganization of the summit in China. Unable to endure the long meetings, he becomes frustrated when the Chinese take advantage of his absence to drag their feet over North Korea. Back at the White House, Josh is told by NASA that a large asteroid is on a collision course with earth; staffers are unsure whether to prepare for the end of the world or not. Donna becomes frustrated when Josh continually postpones what she says is an important conversation. With the New Hampshire primary looming and Vinick looking like a formidable opponent, Josh and Leo try to find a Democratic presidential candidate they can believe in.