Sofia Reyes spreads herself in Daniel's office to prove her power. But, instead of paying attention to him Sofia is interested in Betty's opinions and ideas. Fearing that his assistant is not challenged enough by her job, Daniel sends Betty off to write a review about a hotel where she is supposed to stay at over the weekend. Actually, Betty has planned to spend the weekend with Walter in Atlantic City, but now has to cancel this trip. When, Walter pays her a surprise visit at the hotel, Betty is at first very relieved to see him. But, when Betty continues her review observations of the hotel, Walter is not very helpful. Meanwhile, at MODE, Daniel, who is still interested in Sofia, continues to try to get her attention, but Sofia seems to be very resistant to his charms. And, Wilhelmina has a meeting with an important client, but has to dress up for this meeting in very unusual clothes for her and as it turns out she has to do much more to please him.. At home, Hilda still tries to get the money together the family needs for a lawyer. Being very desperate, she asks Santos, who gives her the money, but in exchange wants to see his and Hilda's son Justin.

To his dismay, Daniel must attend his family's Thanksgiving gathering at the Country Club. Meanwhile, Amanda and Marc create their own gathering at Mode and there is also a dinner at Betty's house where Santos, Justin's father, is in attendance. Meanwhile, Wilhelmina also hosts a Thanksgiving dinner as well but her feast doesn't look as good as it does in magazine pictures.

The day after Thanksgiving is no holiday for Betty, who struggles to pull together a last-minute Mode photo shoot with a famous couple and their baby. Meanwhile, Daniel suffers from the after effects of drinking whilst getting over Sofia and ends up spending the holiday with Betty's family and Wilhemina and Marc get 'lost' in Queens!

Alexis' shocking announcement causes great commotion at both Mode and the Meade home. Betty tries to maintain the peace and order at Mode, however, she is about to face her own personal turmoil when Henry asks her out on a date and Walter tells her he's got a big surprise in store - he has been offered a promotion in Maryland. Meanwhile, Whilhelmina plots her next move to conquer Mode and Justin gets sent home from school for fighting.

Daniel reconnects with New York City's top lawyer Grace Chin, which he once stood up for a date in college. Betty befriends Charlie, an out-of-towner she meets at the Mode cafeteria but later discovers to be Henry's girlfriend.

Petra's mother threatens to have Daniel arrested for sex with a minor unless Petra is put on Mode's cover, but Alexis refuses to allow it unless Daniel resigns.

The season-end cliffhanger: Justin is thrilled with the boy playing Tony in the school play falls mysteriously ill and he is promoted from understudy. Santos finds trouble when he stops at a store to buy Justin a good-luck present. Alexis finds an unpleasant surprise when she takes their father's car to rush Daniel to the hospital for an overdose.

After so many sad events in Betty's life, she can't seem to get her life into perspective. She denies that she is wrecked by the fact that Henry is leaving. Amanda on the other hand is shocked after discovering who her real mother is. Of course, Wilhelmina is right around the corner arranging to take advantage of everything going on around her.