When the team investigates the disappearance of a man, they find pictures of child pornography in his home office and on his computer - all of the same little girl. However, the man who initially appears to be a pedophile on the run quickly becomes a helpful aid with the good intent of finding this little girl who has been subjected to a life of human trafficking and child prostitution.

Jack's friend Max Cassidy vanishes after leaving a message on his wife Anne's voice-mail. While investigating, Jack realizes that Max was having an affair, and that he has got in much deeper into an espionage case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team try to find Max.

The FBI investigates the disappearance of Cole Warren, an FDNY paramedic who was last seen at the hospital after delivering a wounded gang banger. Warren is good at his job and is highly respected. He's stayed in his neighborhood and takes dangerous calls. He was a gang banger himself at one point and managed to get out of that life. He's taken an interest in a young man with the potential to make something of himself and not fall into the spiral that leads so many to crime and violence. Warren's past however catches up with him anyway. Meanwhile, Malone has to deal with his father's funeral and his relationship with Anne Cassidy.

Missing: one suburban housewife. Last seen arguing with a man outside of a Soho gallery. Husband more than a little worried.

Pete and Joanie McMurphy report their teen daughter, Kelly, whom he coaches intensely aiming at Olympic ice skating, missing. The team finds a peeping Tom a false trail. The team finds the school has a problem with doping, and she's obsessed with the death of her doting, more gifted elder brother and mentor Jason, whose death wasn't an accident but the result of steroids for lack of alternative to meet Pete's unrealistic expectations.

Former ADA Jennifer Nichols, now senior partner in a 'social' law firm, disappears after a visit form her allegedly stalking-prone ex Eric Jensen, but he proves inoffensive. She recently visited in jail Grant Stoker, the only caught member of a violent robber gang, and tricked him into betraying the mastermind. Jack suspects travel agency entrepreneur Allen Davis, who dated her but was bothered in the restaurant by the pregnant Lucy Stoker, adulterous wife of Grant who took the blame for her sake. Smelling a rat in the FBI office, Davis seizes the initiative drastically.

A wife and mother secretly working as a stripper disappears, and one of her co-workers turns up dead. Elena takes a job there to investigate undercover, and Danny becomes one of her "clients."

A mentally disturbed woman disappears after a priest performs an exorcism on her. Everyone suspects that she was having strange visions, but the investigation reveals that she may have witnessed a real murder.

The disappearance of a social worker could be related to a bad decision he made that resulted in a young child's death.

The disappearance of a teenage high school basketball star exposes the shady underside of college basketball recruiting, and Jack and Anne have to deal with her miscarriage.