Competition between the maid of honor and a bridesmaid, over who is the bride's best friend, threatens to upend the life of an out-of-work pastry chef.

Eleven years after the events of the Clerks, Dante Hicks (Brian O'Halloran) opens the Quick Stop convenience store to find that it is on fire; Randal Graves (Jeff Anderson) had left the coffee pot on after closing the night before. As a result of the destruction of Quick Stop and the adjacent RST Video, Dante and Randal begin working at a Mooby the Golden Calf fast food restaurant along with Elias (Trevor Fehrman) and their manager List of View Askewniverse characters#Becky Scott (Rosario Dawson). A year later, Dante is planning to leave his minimum wage lifestyle in favor of a family life in Florida with his fiancée Emma Bunting (Jennifer Schwalbach Smith), whose father will provide them with a home and a business to run. This leaves Randal, who fears that with Dante moving to Florida would leave him without his best friend, bitterly disappointed. Jay and Silent Bob (Jason Mewes and Kevin Smith) have since followed Dante and Randal, and now loiter outside of Mooby's. Jay and Silent Bob no longer do drugs after they were arrested for possession and were sent to Drug rehabilitation, and become devout Christians following their release. However, the duo continue selling drugs.

Jim, Oz, Kevin and Stifler are back -- and hornier than ever! After their first year of college, they reunite and rent a beach house for the summer.

David Marks, a real estate scion, is suspected of killing his wife Katie, who disappeared in 1982.

While on a date in a fancy restaurant with Michelle, Jim is ready to propose to her. His father calls to inform him that he has the ring. Michelle misinterprets when Jim stalls the question. Jim's dad arrives as Jim is receiving fellatio, and a mishap grasps the restaurant's attention. Jim proposes and Michelle accepts.