When a body is found in a foam party, he is identified by Grissom and Capt. Brass as the male prostitute Trey Buckman. Meanwhile, Catherine and Nick investigate a decomposed body of the also male prostitute Croix Richards in his apartment. Catherine receives a phone call from Eddie's phone, who is with Lindsey, with poor reception, but soon she learns that Lindsey is screaming and she leaves the crime scene to seek out her daughter. She finds Lindsey in a car in the water but she rescues her. Sara and Det. Vega investigate the case and they suspect that Eddie is dead. Meanwhile Grissom concludes that both victims may have been dead by insulin and they were employees of Lady Heather. Grissom and Catherine visit the suspect Rebecca and meet her husband Steven McCormick that tells to them a weird story. Then he goes with Capt. Brass to Lady Heather's house. Grissom has a personal moment with Lady Heather and when he learns that she is diabetic, he requests a warranty to get her insulin.

When a Hummer in the wrong way runs over an old Fiero, Grissom meets Capt. Brass to investigate the scene. He learns that the Hummer's driver has fled and the Fiero's driver is alive in the hospital. At a car convention, when the host Mr. Daluca opens the curtains to show the latest RV model to the audience, there is a dead woman. Warrick and Det. Louis Vartann learn that the victim is the twenty-nine-year-old model Lisa Schumacher. Dr. Robbins tells Catherine that Lisa was asphyxiated and she had sex before her death. Daluca becomes their prime suspect. Meanwhile, the model Gwen that is working at the convention, goes to the house of her personal trainer Paul Charles to workout and sees him dead through the window. Greg and Sara investigate the crime scene while Dr. Robbins carries out the autopsy. When he sees a black substance in his eye, Hazmat takes Sara and Greg to the decontamination shower. When the body of a boy is found on a bus stop bench covered by a blanket in front of a laundromat, Nick investigates the case. Dr. Robbins tells Nick that the cause of death was asphyxia from heat damage. They identify the victim is Chase Ryan and Nick tries to understand what might have happened to the boy.