At CERN, Father Silvano and Dr. Vittoria Vetra create three canisters of antimatter. Silvano is murdered, and one of the canisters is stolen. The Roman Catholic Church mourn the sudden death of Pope Pius XVI, and prepare for the papal conclave to elect his successor in Vatican City. Father Patrick McKenna, the Camerlengo of the Holy Roman Church, takes control of the Vatican. Four of the “preferiti”, the favoured candidates to be Pope, are kidnapped by a man claiming to represent the Illuminati. He sends the Vatican a warning, claiming he will murder each of the cardinals from 8pm to midnight, where the stolen antimatter will explode and destroy the city, hidden somewhere within.

Dom Toretto and his family are targeted by the vengeful son of drug kingpin Hernan Reyes.