Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Doctors Manning and Charles have a 16-year-old patient with abdominal pain who refuses to take drugs, while Dr. Halstead has a patient who turns out to be an old high school classmate.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.

The doctors of Chicago Med experience various changes.

Sharon's childhood sweetheart arrives at the hospital, while Halstead tries to get his finances in order.

Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.

April discovers her TB medication may lead to further problems, while Dr. Choi learns an important lesson as he treats two MMA fighters who are in bad shape.

Maggie faces her past when the police officer who arrested her is brought into Chicago Med with a serious injury.

Dr. Reese endures a long night on the graveyard shift, while Dr, Rhodes is asked to work on a most unusual patient.

Dr. Latham is talked into going with Dr. Rhodes on a medical trip out of town; an 8-year-old cancer patient wants to give up; a woman with a personality disorder makes a case complicated.

Dr. Rhodes is under pressure to keep a trauma patient alive and April befriends a patient with a failing heart.

Choi and Halstead argue over how to treat a patient with stroke symptoms while Manning treats a boy who fell in the river and watches the family drama unfold.