Horatio and the team, reunited, encounter the Mala Noche gang while investigating a shooting that killed an officer and the rape of a maid.

A case involving the death by shark of a young woman, takes many paths.

The search is on for a young woman who disappeared from a club, and an old case of Horatio's resurfaces.

Tobey Hollins is caught by the Miami Police Departement and is sent to prison for murder. Horatio has some doubts about Tobey's guilt, since some evidences clearly identify some one else as the murderer. Horatio and his team now try everything to disprove Tobey's guilt.

Pool employee Armando Diaz's bloodily battered corpse is found in Craig Seaborn's 5-star hotel Graciana's gardens. He was killed in the penthouse, where three wives had a 'husbands nor sex' weekend. Beth Jacobson admits she had sex with him, but when he called her too unattractive to get hard a fight ensued, so she struck him with a towel bar, thrice. He also had safe sex with Felicia Hardy, who claims she didn't realize he was badly wounded when passing out after hitting his head against the bed. Wolfe follows a third blood trail, to the staircase and more suspects. It must all be tied in. Meanwhile chief James Burton warns Horatio his team is under scrutiny, just now there are tensions about sticking up evidence kits, labor division and Wolfe's media ambitions, apparently paying off a TV reporter.

A killer who has it out for Horatio surfaces in Miami, and frames him for a murder.

Henry Darius, a man who killed several women in New York, claims that he also killed a woman in Miami and offers to show them where he buried her. The plane transporting him suddenly has to make an emergency landing and Dairus escapes. He kills some people to get their car. Horatio learns that the plane was sabotaged and he thinks Darius had a hand in it. Horatio sends for New York Detective Mac Taylor who was the one who caught Darius. Horatio decides to look at the woman's disappearance again and discovers that the husband didn't tell him some things that could have helped him find his wife. Darius continues to go on a killing spree and Horatio learns that Darius is not the killer, so he has to find out how Darius knew about the woman.

Ryan Wolfe, with a nail knocked next to his eye, is being carried to hospital by Delko. There, Horatio remembers how the day started, with the discovery of a murdered woman who was attacked by someone with a nails gun.

During an early morning trip to the bank, Delko ends up witnessing a robbery and fatally shooting one of the suspects. As the investigation progresses, Wolfe realizes that the robbers are trying to replicate a violent video game.

When a drug dealer is gunned down in his home, Horatio and the team must determine who, out of three suspects, committed the crime. Meanwhile, Delko faces a serious threat to his career, and Calleigh makes a decision about hers.

New technology on DNA testing reveals that a man convicted of a rape six years back is innocent and he is promptly released. Now a free man, he is eager on pressing charges against the department and the crime lab for his false conviction. Meanwhile, Horatio and his team reopen the case in hope to catch the real rapist. In the morgue, Alexx examines the body of a young woman who died from infections caused by a piece of cloth left inside her after an operation. She is intent on finding the surgeon responsible for this untimely death.

A participant in a seminar on how to pick up women is found murdered after he's "closed the deal." Elsewhere, Marisol gets into trouble that affects the lab.

Horatio and his team investigate a double murder at a concert, but unraveling the mystery becomes difficult when leads take them in two directions: the Mala Noche gang, and a pharmaceutical company.

The owner of a club is found hanging from a bridge, with two shots in his eyes and a joker card in his pocket. At first it looks like a Mafia work, but the suspects list drastically changes when the CSI team discovers that the murder is described in the script of an upcoming movie.

A trip to the beach for Eric Delko turns sour when a body is uncovered beneath the sand. The man was killed elsewhere and dumped here. Elsewhere, Horatio is certain that his old enemy from New York is back when two murders occur in Miami. He immediately contacts Jennifer Wilson whose parents were killed by the same murderer, Walter Resden, many years back when she was still a little girl.

The murder of a paroled pedophile leads the team to many suspects, one of them at the lab.

As a murder investigation becomes more complicated, Caine must ask Natalia to reveal something from her past in order to solve it.

The team works to implicate a man, after he is acquitted, when the body of his wife finally turns up.

A robbery at a spa injures Marisol, and a hunt starts for the three thieves before more are hurt.

The team ends up trying to help recently released suspects who may be in danger because of money they've stolen.

A misdialed cell phone number sends the team on a desperate search for a kidnapper.

When a man is killed by sharks after going overboard a cruise ship, the team finds multiple suspects and another missing passenger.

A spoiled heiress is found dead in her bathtub during her own party, and the investigation puts Horatio on the trail of an abducted young girl. Horatio tells Delko of his marriage plans.

As Horatio and the team are on the verge of putting away members of the dangerous Mala Noche gang, a tragedy strikes.

The hunt for Riaz continues against the stress of the FBI taking over the lab based on an anonymous tip and one of their own being killed.