Patients include a pregnant teacher whose student/lover was critically injured while driving; a man who is hiding a gunshot wound and a brilliant young boy who knows he is dying, but hides it from his mother. Dr. Moretti continues to remake the ER to his liking, Neela is recovering, Luka's absence is reinforced (back in Croatia and not coming back) and Sam may be starting a new relationship with a police officer.

Abby and a distracted Morris work to save two auxiliary cops brought in with gunshot wounds. Pratt treats a teen wrestler with severe vomiting, but the problem is much more serious. Sam worries over her new beau Litchman. Gates tries to help a young boy in the ICU with a deadly disease. Also, Dubenko visits Neela while she babysits baby Joe.

When Baby Joe is injured by a fall at the playground and rushed to the hospital, Abby is unable to reach Luka to tell him.

Moretti brings in new attending Skye Wexler to help with the patient load. Morris and Pratt cram for the medical board exam. Gates treats a returning patient from the ICU whose condition has worsen. Sam tends to a teenage girl who is feeling neglected by the staff. Neela's intern, Harold, seeks her advice on a personal matter. Abby struggles with her relapse.

Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.

Abby deals with her upcoming reunion with Luka in Croatia, a heart transplant patient is admitted when her body rejects the new heart, and a new doctor ruffles feathers.